grant
Reversing age-related epigenetic changes and characterizing microglia heterogeneity in obesity and aging
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 1 Dec 2022Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2025AddressAffectAffinity ChromatographyAgeAgingAmmon HornAnimalsApplied SkillsAssayBODIPYBS-seqBioassayBioinformaticsBiological AssayBiologyBisulfite-based sequencingBlood PlasmaBlood VolumeBody TissuesBrainBrain Nervous SystemCaloric RestrictionCell BodyCell NucleusCellsChemotactic CytokinesCommunicationCornu AmmonisDNADNA MethylationDNA ModificationDNA Modification ProcessDataDegenerative Neurologic DisordersDeoxyribonucleic AcidDevelopmentDiseaseDisorderDysfunctionElementsEncephalonEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpigenetic ageFatsFatty acid glycerol estersFluorescence Activated Cell Sorting FractionationFluorescence-Activated Cell SortingFluorescence-Activated Cell SortingsFoundationsFunctional disorderFutureGene ExpressionGenesGenomicsGoalsGrantGrimAge clockHannum clockHeterogeneityHigh Fat DietHippocampusHomologous Chemotactic CytokinesHortega cellHorvath clockImmune Cell ActivationImpairmentInflammationInflammatoryIntercrinesInterventionKnowledgeLaboratoriesLeannessLipidsMacrophageMaintenanceManuscriptsMentorsMessenger RNAMethylationMiceMice MammalsMicrogliaModelingMolecularMorphologyMurineMusMφNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNon-Polyadenylated RNANuclearNucleusNutritionalObese MiceObesityOperative ProceduresOperative Surgical ProceduresOralPathologicPatternPhagocytesPhagocytic CellPhasePhenoAge clocksPhenotypePhysiologicPhysiologicalPhysiopathologyPlasmaPlasma SerumPopulationRNARNA Gene ProductsRNA SeqRNA sequencingRNAseqResearchReticuloendothelial System, Serum, PlasmaRibonucleic AcidRibosomesRoleSIS cytokinesSalineSaline SolutionScientistSiteSortingStructureSurgicalSurgical InterventionsSurgical ProcedureTechnical ExpertiseTechniquesTechnologyTestingThinnessTissuesTrainingTranslatingWritingadiposityaffinity purificationage associatedage associated alterationsage associated changesage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage groupage induced alterationsage induced changesage linkedage relatedage related alterationsage related changesage reversalage specificage specific alterationsage specific changesaged brainaged miceaged mouseagesaging associated alterationsaging associated changesaging brainaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging induced epigenetic changeaging preventionaging preventive interventionaging related alterationsaging related changesaging reversalaging specific alterationsaging specific changesaging-associated epigenetic changeaging-related epigenetic changealleviate age relatedalleviate agingalterations with ageamebocyteameliorating aginganti aginganti geronicanti-aging interventionantiagingbisulfite sequencingbisulfite-seqcalorie restrictioncareercell typechanges with agechemoattractant cytokinechemokinecorpulencecounter age relatedcounter agingcounteract age relatedcounteract agingcytokinedecline in functiondecline in functional statusdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdevelopmentaldiet-associated obesitydiet-induced obesitydiet-related obesitydietaryelderly miceentire genomeepigenetic age clocksepigenetic agingepigenetic clockepigenetic mechanisms in agingepigenetic modifications in agingepigenetic molecular clocksepigenetic regulation of agingepigeneticallyepigenomeepigenome editingepigenomic editingepigenomicsexperiencefull genomefunctional declinefunctional status declinegitter cellhippocampalimmune activationimprovedinnovateinnovationinnovativeinsightinterestinterventions targeting aginglab experiencelab traininglaboratory experiencelaboratory traininglate in lifelate lifemRNAmesogliamethylation clockmicroglial cellmicrogliocytemolecular phenotypemouse modelmurine modelneural inflammationneurodegenerative illnessneuroinflammationneuroinflammatorynew approachesnovel approachesnovel strategiesnovel strategynutritiousob/ob mouseold micepathophysiologyperivascular glial cellpreventprevent age relatedprevent agingpreventingrejuvenating interventionrejuvenation approachrejuvenation strategiesrejuvenation therapyrejuvenation treatmentresponsereverse agereverse agingreverse aging effectsreversible agingscRNA sequencingscRNA-seqsexsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskillssocial rolesuppress agingsurgerysystemic inflammationsystemic inflammatory responsetechnical skillstherapeutic rejuvenationtranscriptome sequencingtranscriptomic sequencingtranscriptomicstranslational studytranslatomeuptakewhole genome
Description preview
Project Summary
Neuroinflammation is a hallmark of brain aging that may contribute to declines in function and neurodegenerative
diseases. As the resident macrophage of the brain, microglial are crucial to brain maintenance but have been
demonstrated to take on pro-inflammatory phenotypes with aging. The proposed research will examine the role
of…
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