grant
Reversing abnormal metabolism in mild autonomous cortisol secretion (MACS)
Organization MAYO CLINIC ROCHESTERLocation ROCHESTER, UNITED STATESPosted 20 Feb 2026Deadline 31 Dec 2030
NIHUS FederalResearch GrantFY20262-methyl-1,2-di-3-pyridinyl-1-propanone21+ years oldACTHAccelerationAcetylationAddressAdrenal AdenomaAdrenal Gland AdenomaAdrenal Gland ExcisionAdrenal Gland InsufficiencyAdrenal GlandsAdrenal InsufficiencyAdrenal gland hypofunctionAdrenalectomyAdrenalsAdrenocorticotropic HormoneAdrenocorticotropinAdultAdult HumanAdverse ExperienceAdverse eventAeroseb-HCAffectAndrogenic AgentsAndrogenic CompoundsAndrogensAwardBenign Adrenal AdenomaBenign Adrenal Gland AdenomaBilateralBiological MarkersBlood SerumBranched-Chain Amino AcidsCDK4ICDKN2CDKN2 GenesCDKN2ACDKN2A geneCMM2Cardiometabolic DiseaseCardiometabolic DisorderCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell AgingCell SenescenceCellular AgingCellular SenescenceCetacortCircadian RhythmsClinical TrialsCognitionCommunicationCort-DomeCortefCortenemaCorticotropinCortisolCortisoneCortisprayCortrilCushing SyndromeCushing's basophilismCyclin-Dependent Kinase Inhibitor 2A GeneDataDermacortDexamethasoneDiagnosisDoseDyslipidemiasEldecortEventFDA approvedFeedbackGlucocorticoidsGlycoproteinsHealthHeart VascularHormonalHydrocortisoneHydrocortoneHypertensionHypoadrenalismHypophysisHypophysis CerebriHypothalamic structureHypothalamusHytoneINK4INK4AImpairmentInflammationIntermediary MetabolismInterventionInterviewLeadLipoproteinsMTS1MTS1 GenesMeasurementMedicalMetabolicMetabolic ProcessesMetabolismMethbipyranoneMethopyraponeMetyraponeMorbidityNIDDKNational Institute of Diabetes and Digestive and Kidney DiseasesNutracortNyctohemeral RhythmOutcomePatientsPb elementPituitaryPituitary GlandPituitary Nervous SystemPopulationPrevalenceProctocortQuestionnairesRandomizedRelative RisksReplicative SenescenceResearchSafetySalivarySerumSteroid CompoundSteroid biosynthesisSteroidsSymptomsT-CellsT-LymphocyteTP16TSG9ATestingTherapeutic AndrogenTwenty-Four Hour RhythmUnited StatesUrineVascular Hypertensive DiseaseVascular Hypertensive DisorderWithdrawaladulthoodarmbio-markersbiologic markerbiomarkerbone healthbranched amino acidscardiovascular riskcardiovascular risk factorcircadiancircadian processcircadian rhythmicitycirculatory systemdaily biorhythmdouble-blind placebo control trialdouble-blind placebo controlled trialdouble-masked controlled trialfrailtyheavy metal Pbheavy metal leadhigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderhypothalamicimprovedinflammation markerinflammatory markerinhibitormetabolic phenotypemetabolomemetabonomemetabotypemortalitynatural agingnormal agingnormative agingopen labelopen label studyp14ARFp16 Genesp16INK4 Genesp16INK4A Genesp16INK4apatient populationperipheral bloodpituitary basophilismpost interventionrandomisationrandomizationrandomly assignedreplicative agingsenescencesenescentsteroidogenesissuprarenal glandsystemic inflammationsystemic inflammatory responsethymus derived lymphocyte
Description preview
PROJECT SUMMARY
Mild autonomous cortisol secretion (MACS) is diagnosed in up to 44% of patients with adrenal adenomas,
affecting 1-2% of the adult population. MACS is diagnosed based on an abnormal cortisol level following
dexamethasone suppression (>1.8 mcg/dL). Patients with MACS develop high rates of cardiovascular
morbidity and demonstrate…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click