grant

Revealing the RNA foundations of chromatin-based epigenetics

Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Mar 2024Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY2026Active Follow-upAcuteAntsBinding SitesBiochemicalBiochemistryBiologic ModelsBiological ChemistryBiological ModelsBiotechBiotechnologyCell BodyCell DifferentiationCell Differentiation processCellsChemicalsChromatinCombining SiteDiseaseDisorderES cellES cell differentiationESC differentiationEngineeringEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEventFliesFoundationsFunctional RNAGene Down-RegulationGeneticGoalsHealthKnock-outKnockoutLaboratory StudyMammaliaMammalian CellMammalsMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMedicineMethodsModel SystemModificationMolecularMouse ES CellMouse ESCMouse Embryonic ProgenitorMouse Embryonic Stem CellsNerve CellsNerve UnitNeural CellNeurocyteNeuronsNon-Polyadenylated RNANoncoding RNANontranslated RNANucleic Acid Biochemistry, RNA - Ribonucleic AcidPathway interactionsPlayPolycombProcessProteinsProteomeRNARNA BindingRNA BiochemistryRNA Gene ProductsRNA Nucleic Acid BiochemistryRNA and protein interactionRNA boundRNA-Protein InteractionReactive SiteRegulationResearchRibonucleic AcidRoleShapesSystemTechnologyTranscription RepressionUntranslated RNAWorkYeastsactive followupcellular differentiationdesigndesigningdifferentiation in embryonic stem cellsdirected differentiationembryo derived stem cellembryonal stem cellsembryonic precursor differentiationembryonic progenitorembryonic stem cellembryonic stem cell differentiationepigenetic memoryepigeneticallyextracellular vesiclesflyfollow upfollow-upfollowed upfollowupfunctional genomicsgene repressiongenome scalegenome-widegenomewidemESCmodel organismmurine ES cellsmurine ESCmurine embryonic progenitormurine embryonic stem cellmutantmutation scanningmutation screeningneuronalnoncodingpathwayprotein complexrecruitsocial rolestem cell of embryonic origin
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PROJECT SUMMARY
The goal of this proposal is to determine how the crosstalk between RNA and chromatin shapes epigenetic

states in pluripotent and differentiated cells.

My laboratory studies epigenetic memory, both at a mechanistic level, using biochemistry and functional

genomics in mouse embryonic stem cells, and at an organismal level, using…

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Revealing the RNA foundations of chromatin-based epigenetics — UNIVERSITY OF PENNSYLVANIA | UNITED STATES | Mar 2024 | Dev Procure