grant
Retinal Modulation of Basal Forebrain Circuits
NIHUS FederalResearch GrantFY2025AcetylcholineAcuteAnatomic SitesAnatomic structuresAnatomyAnimal BehaviorAnimalsAreaArousalAttentionBehaviorBehavioralBrainBrain Nervous SystemBrain regionCell BodyCell Communication and SignalingCell NucleusCell SignalingCellsCuesCyclicityDataElectrophysiologyElectrophysiology (science)EncephalonEndowmentEnvironmentGlutamatesGoalsIntracellular Communication and SignalingL-GlutamateLearningLightMapsMediatingMemoryMoodsMorphologyNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeuropeptidesNeurophysiology / ElectrophysiologyNucleusOrganismOutputPathway interactionsPeriodicityPhotoradiationPlayPopulationPositionPositioning AttributeResearchRetinaRetinal Ganglion CellsRhythmicityRoleSignal TransductionSignal Transduction SystemsSignalingSleepSpecificitySubconsciousSystemTestingTracerViralVirusWorkbasal forebrainbehavior influencebehavioral influencebiological signal transductioncell typecholinergiccholinergic neuroncircadianconditioned fearelectrophysiologicalenvironmental changeexperimentexperimental researchexperimental studyexperimentsfear conditioningflexibilityflexiblefunction luminancegene manipulationgenetic manipulationgenetically manipulategenetically perturbglutamatergicinsightliving systemluminancemelanopsinneuralneural adaptationneural circuitneural circuitryneural controlneural regulationneuroadaptationneurocircuitryneuromodulationneuromodulatoryneuronalneuroregulationneurotransmitter releasepathwayresponseretinal ganglionsocial rolesynaptic circuitsynaptic circuitryvisual information
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PROJECT SUMMARY
Light is a ubiquitous feature of the natural environment and plays a central role in modulating an organism’s
internal state. This flexible adaptation of neural circuits is essential for an organism’s survival. It endows them
with not only the ability to preemptively adapt neural circuits to rhythmic, predictable changes in light…
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