grant
Restoring Gastrointestinal Microbiota-Host Interactions to Prevent Invasive Candidiasis
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 13 Feb 2026Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY202621+ years old5-Aminosalicylic AcidAblationAcidsAcute leukemiaAdultAdult HumanAfter CareAfter-TreatmentAftercareAgonistAlimentary CanalAnaerobiosisAntibiotic AgentsAntibiotic DrugsAntibiotic TherapyAntibiotic TreatmentAntibioticsAntimicrobial ResistanceApproaches to preventionAsacolAutoregulationBacteriaBiologyBlood CirculationBloodstreamButyratesC albicansC. albicansC.albicansC57BL/6 MouseCO2CTXCYCLO-cellCancer TreatmentCancersCandidaCandida albicansCandidiasisCandidosisCarbon DioxideCarbonic AnhydrideCarloxanCategoriesCausalityCellular Immune FunctionCiclofosfamidaCiclofosfamideCicloxalClafenClapheneClassificationColonCycloblastinCycloblastineCyclophosphamCyclophosphamideCyclophosphamidumCyclophosphanCyclophosphaneCyclophosphanumCyclostinCyclostineCytophosphanCytophosphaneCytoxanDataDefense MechanismsDevelopmentDevelopment and ResearchDigestive TractDiseaseDisorderDrugsEndoxanEndoxanaEnduxanEngraftmentEpitheliumEtiologyFecesFosfaseronFungal Drug ResistanceFungus drug resistantGI TractGI colonizationGI microbiotaGastrointestinal TractGastrointestinal microbiotaGastrointestinal tract structureGeneralized GrowthGenoxalGenuxalGnotobioticGnotobioticsGoalsGrowthGut EpitheliumHematologic CancerHematologic MalignanciesHematologic NeoplasmsHematological MalignanciesHematological NeoplasmsHematological TumorHematopoietic CancerHomeostasisHumanHypoxiaHypoxicImmune systemIndividualInfectionInflammatory Bowel DiseasesInflammatory Bowel DisorderIntermediary MetabolismIntestinalIntestinesInvestigatorsLedoxinaLeftLiverMalignant Hematologic NeoplasmMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMediatingMedicationMesalamineMesalazineMetabolic ProcessesMetabolismMiceMice MammalsMicrobeMiscellaneous AntibioticMitochondriaMitoxanModelingModern ManMoniliaMoniliasisMurineMusNeosarO elementO2 elementOutcomeOxygenOxygen ConsumptionOxygen DeficiencyPPAR gammaPPAR-gPPAR-γPPARgammaPPARγPatientsPentasaPeroxisome Proliferative Activated Receptor GammaPeroxisome Proliferator-Activated Receptor gammaPeroxisome Proliferator-Activated Receptor γPersonsPharmaceutical PreparationsPhysiological HomeostasisPopulationPost-vaccination infectionPrevention approachProcytoxProphylactic treatmentProphylaxisR & DR&DResearchResearch PersonnelResearch ResourcesResearchersResourcesRisk ReductionRowasaSendoxanShort-Chain Fatty AcidsSpleenSpleen Reticuloendothelial SystemStreptomycinSupplementationSyklofosfamidSystematicsTestingTherapeuticTherapeutic FungicidesTherapeutic InterventionThiazolidinedione ReceptorTissue GrowthVolatile Fatty AcidsWorkWorld Health OrganizationZytoxanadulthoodalimentary tractanti-cancer therapyanti-fungalanti-fungal agentsanti-fungal druganti-fungal drug resistanceanti-fungal drug resistantanti-fungal resistanceanti-fungal resistantanti-microbialanti-microbial resistantanti-microbial resistant infectionantimicrobialantimicrobial resistant infectionbacterial disease treatmentbacterial infectious disease treatmentbowelbreakthrough infectioncancer therapycancer-directed therapycandidaemiacandidemiacausationchemotherapycolonization resistancedevelopmentaldigestive canaldisease causationdrug/agentdysbacteriosisdysbiosisdysbioticenteric microbial communityenteric microbiotaexpectationexperimentexperimental researchexperimental studyexperimentsfecal samplefungal pathogenfungi pathogenfungusfungus drug resistancegastrointestinalgastrointestinal epitheliumgastrointestinal microbial floragastrointestinal tract colonizationglobal healthgut colonizationgut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microflorahepatic body systemhepatic organ systemhigh riskhost microbiotahost microflorahuman florahuman microbial communitieshuman microbiotahuman microflorahuman-associated microbial communitieshuman-associated microbiotaimmune functionimproved outcomeinflammatory disease of the intestineinflammatory disorder of the intestineinnovateinnovationinnovativeinsightinterestintervention therapyintestinal autoinflammationintestinal colonizationintestinal floraintestinal microbiotaintestinal microfloraintestinal tract microfloram-Aminosalicylic Acidmalignancymeta-Aminosalicylic Acidmicrobialmicrobial consortiamicrobial floramicrobial imbalancemicrobiotamicrofloramitochondrialmortalitymultispecies consortianeoplasm/cancernew approachesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel approachesnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapy targetontogenyopportunistic pathogenpathogenpathogenic funguspost treatmentpreventpreventingprophylacticpsychological defense mechanismreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskresearch and developmentresident microbesresident microfloraresistance to anti-fungalresistance to anti-microbialresistant to anti-fungalresistant to antimicrobialrestorationrisk-reducingstoolstool samplestool specimensugaryeast infection
Description preview
PROJECT SUMMARY
The World Health Organization classified Candida albicans as a critical pathogen warranting increased
research and development needs. C. albicans is the most common etiology of invasive candidiasis, which
occurs when C. albicans enters the blood stream (candidemia) and disseminates throughout the body (i.e. the
liver and spleen)…
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