grant
Restoring Cognitive Flexibility After Adolescent Cocaine Exposure Using Psilocybin
Organization ALBERT EINSTEIN COLLEGE OF MEDICINELocation BRONX, UNITED STATESPosted 8 Apr 2026Deadline 7 Apr 2029
NIHUS FederalResearch GrantFY202612-20 years old2-photon21+ years oldAccelerationAdaptive BehaviorsAddressAdolescenceAdolescentAdolescent YouthAdultAdult HumanAnimalsBehaviorBehavioralBiological MarkersBrainBrain Nervous SystemCNS plasticityCalciumChronicClinical ResearchClinical StudyCocaine use disorderCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalControl AnimalCouplingCuesDataDecision MakingDevelopmentDisturbance in cognitionDrug ExposureDrug TherapyDrugsDysfunctionEncephalonEpidemiological dataEpidemiology dataExhibitsExposure toFeedbackFunctional disorderGoalsHallucinogenic AgentsHallucinogenic DrugsHallucinogenic SubstancesHallucinogensHistoryImageImpaired cognitionImpairmentImplantImpulsivityInterventionInvestigationLearningLinkMedialMedicationMiceMice MammalsMurineMusNeuronal PlasticityPatternPerformancePharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhasePhysiopathologyPopulation DynamicsPrefrontal CortexPsilocibinPsilocybinPsychedelic AgentsPsychedelicsPsychotomimetic AgentsPublic HealthReaction TimeRecording of previous eventsRecoveryResponse RTResponse TimeReversal LearningRewardsRiskSalineSaline SolutionStructureSubstance Use DisorderSynapsesSynapticTestingTherapeuticUpdateWorkadaptation behavioradaptive behavioraddictionaddictive disorderadolescence (12-20)adulthoodbehavioral impairmentbio-markersbiologic markerbiomarkercentral nervous system plasticitycocaine exposurecocaine usecocaine-exposedcognitive controlcognitive dysfunctioncognitive enhancementcognitive losscompare to controlcomparison controlcritical perioddevelopmentaldrug interventiondrug treatmentdrug/agentepidemiologic dataexecutive controlexecutive functionexperimentexperimental researchexperimental studyexperimentsexposed to cocaineexposure to cocaineflexibilityflexiblefrontal cortexfrontal lobehistoriesimagingimpaired behaviorimprovedindexinginsightjuvenilejuvenile humanlater in lifelater lifeneuralneural circuitneural circuitryneural plasticityneurobehavioralneurocircuitryneuroplasticneuroplasticitynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathophysiologypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspre-clinical studypreclinical studypsychedelic drugpsychomotor reaction timepsychotomimetic drugrecruitresilienceresilientsubstance use and disordersubstance use treatmentsynapsesynaptic circuitsynaptic circuitrytwo-photon
Description preview
Project Summary
Adolescence is a critical window for the maturation of prefrontal cortical circuits that support impulse control,
behavioral flexibility, and goal-directed decision making. Cocaine exposure during this period can derail
typical development, leading to persistent impairments in cognitive control and increased vulnerability to…
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