grant
Restoration of Structure and Function in the Diabetic Cornea
Organization WAYNE STATE UNIVERSITYLocation DETROIT, UNITED STATESPosted 1 May 2025Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY202621+ years oldAdultAdult HumanAnteriorBindingBlindnessBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood VesselsBlood monocyteBrittle Diabetes MellitusCataractCell BodyCell Communication and SignalingCell DensityCell FunctionCell LocomotionCell MigrationCell MovementCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCombined Modality TherapyComplexCorneaD-GlucoseDataDendritic CellsDenervationDevelopmentDextroseDiabetes MellitusDiabetic RetinopathyDiagnosisDiseaseDisease OutcomeDisorderEndothelial CellsEndotheliumEpidemicEpidemiologistEpithelial CellsEpitheliumExposure toEyeEyeballFibroblastsFilmFx peptideGlucoseHealthHumanHyperglycemiaIDDMImmunoblottingImpaired tissue repairImpaired wound healingImpairmentIn VitroInflammationInsulin-Dependent Diabetes MellitusIntracellular Communication and SignalingJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKnowledgeLeftMacrophageMarrow NeutrophilMarrow monocyteMeasurementModern ManMolecular InteractionMorphologyMultimodal TherapyMultimodal TreatmentMyofibroblastMφNerveNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeuropathyNeutrophilic GranulocyteNeutrophilic LeukocyteNewly DiagnosedOccluding JunctionsOperative ProceduresOperative Surgical ProceduresPHM27PathogenesisPathogenicityPathologyPathway interactionsPatientsPeptide-based drugPeptidesPersonsPhenotypePolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPreclinical dataPredispositionPrevalencePreventionProteinsPublishingResearch DesignRoleSTZSignal TransductionSignal Transduction SystemsSignalingStreptozocinStreptozotocinStructureStudy TypeSubcellular ProcessSudden-Onset Diabetes MellitusSurgicalSurgical InterventionsSurgical ProcedureSusceptibilityT1 DMT1 diabetesT1DT1DMTRP channelTherapeuticThymosin beta4Thymosin β4Tight JunctionsTimeTransient receptor potential channelType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusVasoactive Intestinal PeptideVasoactive Intestinal PolypeptideVasointestinal PeptideVeiled CellsVisualWestern BlottingWestern ImmunoblottingWound RepairZanosarZonula Occludensabnormal tissue repairadulthoodbiological signal transductioncataractogenesiscataractous lensescell motilityclinical applicabilityclinical applicationcombination therapycombined modality treatmentcombined treatmentcornealcorneal epithelialcorneal epithelial wound healingcorneal epitheliumcorneal wound healingdelayed wound healingdesigndesigningdevelopmentaldiabetesdiabeticdiabetic patientdiscoidin domain receptordiscoidin receptoreffective therapyeffective treatmentglycemic controlhyperglycemicimprovedin vivoinnervationinsulin dependent diabetesinsulin dependent type 1juvenile diabetesjuvenile diabetes mellitusketosis prone diabetesmonocytemouse modelmulti-modal therapymulti-modal treatmentmurine modelnerve supplyneuronalneuropathicneutrophilnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapeuticsnew therapynew therapy approachesnew therapy targetnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy approachnovel therapy targetoccludinpathwaypeptide drugpre-clinicalpreclinicalpreclinical findingspreclinical informationpreventpreventingprotective effectprotein blottingresponserestorationsocial rolestemstudy designsurgerytherapeutic peptidethymosin beta(4)type 1 diabetictype I diabetestype I diabetictype one diabetesvascularvision lossvisual losswound healingwound recoverywound resolution
Description preview
Project Summary/Abstract
Objective/Hypothesis. Diabetes is expected to reach epidemic levels by 2030. Despite the prevalence of diabetic
retinopathy, many adult diabetic patients develop visually disruptive corneal complications, including impaired
wound healing and corneal neuropathy. Unfortunately, treatment for diabetes-induced damage to the…
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