grant
Respiration and fitness in Bacteroides
Organization RENSSELAER POLYTECHNIC INSTITUTELocation TROY, UNITED STATESPosted 8 Jul 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AddressAffectB fragilisB. fragilisBacteriaBacteroidesBacteroides fragilisBile AcidsBiochemicalBiochemistryBiological ChemistryCell FunctionCell PhysiologyCell ProcessCell RespirationCellular FunctionCellular PhysiologyCellular ProcessCellular RespirationCodeCoding SystemColorCommunitiesComplexConsumptionCytoplasmDataDependenceDevelopmental ProcessDietary PolysaccharideDigestionElectron TransportElectronsEndogenous Nitrate VasodilatorEndothelium-Derived Nitric OxideEnzymatic BiochemistryEnzyme GeneEnzymesEnzymologyFermentationFoodFormulationGI microbiomeGI microbiotaGastrointestinal microbiotaGeneralized GrowthGenerationsGenesGeneticGlycansGnotobioticGnotobioticsGrowthH+ elementHealthHealth BenefitHumanHydrogen IonsHydrophobicityImmune RegulatorsImmunomodulatorsIn VitroIndustrializationInflammationIntermediary MetabolismIon PumpsMenaquinoneMetabolic ProcessesMetabolismModern ManMononitrogen MonoxideMonosaccharidesMultienzyme ComplexesNADHNO2Negative Beta ParticleNegatronsNitric OxideNitritesNitrogen DioxideNitrogen MonoxideNitrogen PeroxideNitrogen ProtoxideNutrientOperonOxidantsOxidizing AgentsPathway interactionsPhysiologyPolysaccharidesPopulationProbioticsProcessProductionPropertyProtonsQuinone CompoundQuinonesRegulationRespirationRespiratory ChainRoleShort-Chain Fatty AcidsSideSocial Support SystemSourceSubcellular ProcessSupport SystemTissue GrowthToxic effectToxicitiesTranslatingVariantVariationVitamin K 2Vitamin K QuinoneVitamin K2Volatile Fatty AcidsWorkaerobic metabolismaerobic respirationantiporterbacteria in the gutbacterial fitnessbowel inflammationdesigndesigningdietarydigestive tract microbiomedisease preventiondisorder preventionelectron acceptorelectron donorelectron transferendothelial cell derived relaxing factorenteric microbial communityenteric microbiomeenteric microbiotaenzyme complexexperienceexperimentexperimental researchexperimental studyexperimentsfitnessgastrointestinal microbial floragastrointestinal microbiomegut bacteriagut communitygut floragut inflammationgut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomeimmune modulatorsimmunomodulatory moleculesimmunoregulatorimmunoregulatory moleculesin vivoinflamed bowelinflamed gutinflamed intestineintestinal biomeintestinal floraintestinal inflammationintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloraisoprenoidmembermenmetabolism measurementmetabolomicsmetabonomicsmicrobialmicrobial consortiamicrobial floramicrobiotamicrobiota compositionmicrofloramouse modelmultispecies consortiamurine modelnitric oxide reductaseontogenyoxidative metabolismpathwaypatient populationprotective effectrespiratoryrespiratory enzymerespiratory mechanismrestorationsocial roletranscriptomics
Description preview
PROJECT SUMMARY/ABSTRACT
Bacteroidales is the most abundant order of bacteria in the human gut, yet we still know little about energy
generating processes of these bacteria and how these systems support their fitness in the gut and affect host
processes. We have demonstrated that Bacteroides have a complex respiratory chain that provides…
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