grant
Resource Core - Barton
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 25 Sept 2005Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AddressAgeAnimalsAnterior Tibial MuscleAssayBioassayBiological AssayBlindedBody CompositionBreedingCell TherapyCollaborationsCommon Rat StrainsCommunitiesComplementComplement ProteinsControl AnimalDNA TherapyDataDiaphragmDrug TherapyDystrophinEquipmentEvaluationForelimbGene Transfer ClinicalGenetic InterventionGoalsHindlimbHindlimb ElevationHindlimb ImmobilizationHindlimb SuspensionHindlimb UnloadingHistologyHouse miceHuman ResourcesIn SituIndividualInjuryInvestigatorsLaboratoriesLettersLiquid substanceManpowerMeasurementMeasuresMechanicsMiceMice MammalsModelingMurineMusMus musculusMuscleMuscle TissueMuscle functionMuscular DystrophiesMyodystrophicaMyodystrophyNitrogenOutcome MeasurePharmacological TreatmentPharmacotherapyPhysiologicPhysiologicalPreparationRatRats MammalsRattusResearchResearch DesignResearch PersonnelResearch ResourcesResearchersResourcesRespiratory DiaphragmRespiratory physiologyRodent ModelRunningSamplingServicesSoleusSoleus MuscleStudy TypeTestingTherapeuticagesbiological sex as a modifiercell based interventioncell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular therapeuticcellular therapycomplementationdrug interventiondrug treatmentexperienceexperimentexperimental researchexperimental studyexperimentsfluidgene repair therapygene therapygene-based therapygenetic therapygenomic therapyinjuriesinstrumentationliquidmeasurable outcomemechanicmechanicalmembermouse modelmurine modelmuscle dystrophymuscle physiologymuscularoutcome measurementpersonnelpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspreparationsrespiratory functionsex as a biological factorsex as a biological measuresex as a biological risk factorsex as a biological variablesex as a biological variancesex as a biologically significant variablesex as a fundamental variableskillsstudy designtibialis anteriortibialis anterior muscletreadmill
Description preview
ABSTRACT
Critical to the evaluation of potential therapeutics (pharmacological, gene, or cell therapies) are sensitive and
repeatable physiological assessments of muscle function applied to mouse models of dystrophy. Therefore,
we are proposing to continue a Recource Core that performs ex vivo, in situ, and whole animal assessments
of muscle…
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