grant
Resolving phenotypic overlap in renal carcinoma subtypes using multi-tiered network methods
Organization DANA-FARBER CANCER INSTLocation BOSTON, UNITED STATESPosted 7 May 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2026Anti-Cancer AgentsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsApplications GrantsArchitectureAttenuatedAwardBasal Transcription FactorBasal transcription factor genesBenchmarkingBest Practice AnalysisBindingBiochemical PathwayBiologicalCancer DrugCancer cell lineCarcinoma CellCell BodyCell LineCellLineCellsChildhoodChimera ProteinChimeric ProteinsClear CellClinicalComputing MethodologiesCytosolDF/HCCDNA AlterationDNA Sequence AlterationDana-Farber Cancer InstituteDataDiagnosisDifferential Gene ExpressionDiseaseDisorderDrug TargetingDrug resistanceDrugsEngineering / ArchitectureEnvironmentFDA approvedFusion ProteinGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene TranscriptionGene variantGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic AlterationGenetic TranscriptionGenitourinary CancersGenomicsGoalsGrant ProposalsGrawitz TumorHeterogeneityHexose Monophosphate ShuntHistologicHistologicallyHypernephroid CarcinomaHypernephromaInstitutionKidney CancerKidney CarcinomaKnowledgeLinkLipidsLiteratureMalignant Epithelial CellMediatingMedicationMentorsMetabolicMetabolic NetworksMetabolic PathwayMethodsModelingMolecularMolecular InteractionMultiomic DataNeoplastic Disease Chemotherapeutic AgentsNephroid CarcinomaNetwork AnalysisOncogenicOncologyOncology CancerOutcomeOxidative PhosphorylationOxidative Phosphorylation PathwayPathway AnalysisPatientsPentose Phosphate PathwayPentose Phosphate ShuntPentose ShuntPentosephosphate PathwayPentosephosphate ShuntPharmaceutical PreparationsPharmacogeneticsPhenotypePopulation GeneticsPost-Translational RegulationPosttranslational RegulationPrediction of Response to TherapyProcessProteinsPublic HealthPublic Health SchoolsQTLQuantitative Trait LociRNA ExpressionRNA SeqRNA sequencingRNAseqRegulatory ElementRenal AdenocarcinomaRenal CancerRenal CarcinomaRenal CellRenal Cell AdenocarcinomaRenal Cell CancerRenal Cell CarcinomaReportingResearchResistanceRoleSample SizeSamplingScienceSequence AlterationSourceStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationStatistical MethodsStrains Cell LinesSurvey InstrumentSurveysTFE3TFE3 geneTherapeuticTherapeutic AgentsTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionTrainingTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTranscription Factor Proto-OncogeneTranscription Factor for Immunoglobulin Heavy-Chain Enhancer 3Transcription factor genesTreatment outcomeTumor-Specific Treatment AgentsUrogenital CancerVariantVariationWorkallelic variantanalyze gene expressionanti-cancer drugattenuateattenuatesbenchmarkbiologicbiomarker identificationcancer geneticscancer genomicscancer progressioncancer sub-typescancer subtypescancers that are rarecareer developmentchemical reaction ratecomparativecomputational methodologycomputational methodscomputer based methodcomputer methodscomputing methodcultured cell linedata integrationdrug efficacydrug resistantdrug/agentepigenetic regulationgene expression analysisgene expression assaygenetic variantgenomic alterationgenomic variantgenotyped patientshuman tissueidentification of biomarkersidentification of new biomarkersimprovedkidney adenocarcinomakidney cellknowledge baseknowledge curationknowledge integrationmarker identificationmetabolic phenotypemetabotypemulti-modal datamulti-modal datasetsmulti-modalitymultidisciplinarymultimodal datamultimodal datasetsmultimodalitymultiple omic dataneoplasm progressionneoplastic progressionnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetoncogenomicspediatricpredict responsivenesspredict therapeutic responsepredict therapy responsepredicting responsepreventpreventingprogramsrare cancerrare malignancyrare tumorreaction rateresistance to Drugresistantresistant to Drugresponseskillssmall molecular inhibitorsmall moleculesmall molecule inhibitorsocial rolestatistic methodsstatistical analysistherapy optimizationtherapy predictiontranscription factortranscriptional profilingtranscriptome sequencingtranscriptomic sequencingtranslational medicinetreatment optimizationtreatment predictiontreatment response predictiontumor progression
Description preview
PROJECT SUMMARY/ABSTRACT
Small sample size in Translocation Renal Cell Carcinoma (tRCC), a rare cancer, hampers our ability to
correctly diagnose this aggressive subtype and to provide patients with efficient therapies. The most important
causes of tRCC misdiagnosis are its heterogenous presentation and overlap with other subtypes such as the…
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