grant
Research Project 2: PFAS and Liver Health in Latino Youth: A Longitudinal Multi-Omics Study
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 24 Apr 2025Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY202612-20 years old18 year old18 years of age21+ years old8 year old8 years of ageAbdomenActive Follow-upAddressAdolescenceAdolescentAdolescent YouthAdolescent obesityAdultAdult HumanAffectAminotransferasesAnimalsApproaches to preventionAreaBioinformaticsBiologicalBiological MarkersBlood PlasmaBlood SerumCaliforniaChemicalsChild HealthCollaborationsCommunicationCross-Sectional StudiesCross-Sectional SurveyDataData AnalysesData AnalysisData Management and Analysis CoreData Management and Statistical Analysis CoreData Management and Statistical CoreData ScienceDietDisease Frequency SurveysDoseEngineeringEnsureEuropean ancestryEvaluationExposure toFatsFatty acid glycerol estersHealthHepaticHepatic DisorderHepatotoxic effectHepatotoxicityHistoryHumanHuman FigureHuman bodyImageImpairmentIndividualInflammationInflammatoryInjury to LiverIntermediary MetabolismInterventionKnowledgeLatinoLifeLiverLiver ToxicityLiver diseasesMR ImagingMR TomographyMRIMRI ScansMRIsMagnetic Resonance ImagingMagnetic Resonance Imaging ScanMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMeta-AnalysisMetabolicMetabolic ProcessesMetabolic dysfunctionMetabolismMetadataMethodsModelingModern ManMultiomic DataNMR ImagingNMR TomographyNuclear Magnetic Resonance ImagingOutcomeOverweightOxidative Stress Induced Gene Expression Via Nrf2Oxidative Stress PathwayPFASParticipantPathway interactionsPhysical activityPlasmaPlasma SerumPoly-fluoroalkyl substancesPopulationPredispositionPreventative strategyPreventionPrevention approachPrevention strategyPreventive strategyProspective cohortProteomicsR-Series Research ProjectsR01 MechanismR01 ProgramRecording of previous eventsResearchResearch DesignResearch GrantsResearch Project GrantsResearch ProjectsRestReticuloendothelial System, Serum, PlasmaRiskSample SizeSamplingSerumStatistical MethodsStudy TypeSubgroupSuperfundSusceptibilityTimeToxic effect on liver cellsToxicologyTraining ProgramsTransaminasesTranslationsVisitWater PollutantsYouthYouth 10-21Zeugmatographyactive followupadolescence (12-20)adult youthadulthoodage 18age 18 yearsage 8age 8 yearsbio-markersbiologicbiologic markerbiomarkerbiomarker signatureclinical practiceco-exposuresco-occurring exposurecohortcombined exposurecommunity engagementcomplex exposureconcurrent exposurecross-sectional research studydata integrationdata interpretationdietseight year oldeight years of ageeighteen year oldeighteen years of ageengagement with communitiesexposure mixturefat metabolismfollow upfollow-upfollowed upfollowuphepatic body systemhepatic damagehepatic diseasehepatic injuryhepatic organ systemhepatic toxicityhepatopathyhepatoxicityhigh dimensionalityhigh risk grouphigh risk individualhigh risk peoplehigh risk populationhistoriesimagingindividualized preventioninnovateinnovationinnovativejuvenilejuvenile humanlife-style factorlifestyle factorslipid metabolismliver damageliver disorderliver injurylongitudinal designlongitudinal experimental designlongitudinal research designlongitudinal study designmeta datametabolism measurementmetabolomicsmetabonomicsmixed exposuremultiomicsmultiple omic datamultiple omicsobese adolescentsobesity among adolescentsobesity during adolescenceobesity in adolescenceobesity in adolescentspanomicspathwayperfluorinated alkyl substancesperfluoroalkyl substancesperfluoroalkylated substancespersonalized preventionpharmacokinetic modelpollutantpolyfluorinated alkyl substancespolyfluoroalkyl substancesprecision preventionprogramsprospectiveremediationresponserisk stratificationsimultaneous exposuressocial health determinantsstatistic methodsstratify riskstudy designsuperfund sitesystematic reviewtranslationwater contaminantyoung adultyoung adult ageyoung adulthoodyouth adiposityyouth age
Description preview
Per- and polyfluoroalkyl substances (PFAS) are ubiquitous, persistent chemicals that can accumulate in the
human body for long periods of time and are major water contaminants around Superfund sites. PFAS partition
to the liver and robust evidence generated by animal toxicological studies shows that PFAS are hepatotoxic,
even at low levels of…
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