grant
Research Project 2 - Genomic Approaches to Pollutome Effects on Risk of Major Depression in Hispanic Pedigrees
Organization UNIVERSITY OF TEXAS RIO GRANDE VALLEYLocation EDINBURG, UNITED STATESPosted 18 Sept 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AffectAgeAir PollutantsAromatic Polycyclic HydrocarbonsArthritisBehaviorBlood PlasmaCausalityCell Communication and SignalingCell SignalingCharacteristicsChemicalsChicanasChicanosClinicalCohort StudiesConcurrent StudiesDataDepressed moodDetectionDiabetes MellitusDiagnosisDioxin CompoundDioxinsDiseaseDisorderDrugsEconomic BurdenEnvironmentEnvironmental EpidemiologyEnvironmental ExposureEnvironmental FactorEnvironmental PollutantsEnvironmental Risk FactorEthnic OriginEthnicityEtiologyExposure toFamilyFamily StudyFeelingFosteringFuransGeneticGenomeGenomic approachGenomicsGenotypeHeritabilityHispanicHumanImmigrationIndividualInfectious AgentIntracellular Communication and SignalingLifeLife StyleLifestyleMajor Depressive DisorderMeasuresMedicationMental DepressionMental disordersMental health disordersMetalsMexican AmericansModern ManModificationNutrientPCBsPedigreePersonsPesticidesPharmaceutical PreparationsPhenotypePlasmaPlasma SerumPolychlorinated BiphenylsPolychlorobiphenyl CompoundsPredisposing FactorPreventionProcessProtocolProtocols documentationPsychiatric DiseasePsychiatric DisorderR-Series Research ProjectsR01 MechanismR01 ProgramRecurrenceRecurrentResearchResearch GrantsResearch Project GrantsResearch ProjectsResearch ResourcesResourcesReticuloendothelial System, Serum, PlasmaRiskRisk FactorsSamplingSignal TransductionSignal Transduction SystemsSignalingSocio-economic statusSocioeconomic StatusStandardizationStimulusStressful EventTestingTimeToxinTriazinesVariantVariationaddictionaddictive disorderagesarthriticbiological signal transductioncausationchlorinated hydrocarbon pesticideclinical depressioncohortcostdepresseddepressiondesigndesigningdiabetesdietarydisease causationdisease riskdisorder riskdrug/agententire genomeenvironmental contaminantenvironmental riskexposomefeelingsfull genomegene locusgenetic informationgenetic locusgenetic pedigreegenome sequencinggenome wide analysisgenome wide studiesgenome-wide analysisgenome-wide identificationgenomic effortgenomic locationgenomic locusgenomic strategygenomic toolsimprovedinfectious organisminsightinterestmajor depressionmajor depression disordermembermental illnessnovelorganochlorine pesticidepedigree structurepersistent organic pollutantspollutantpolyaromatic hydrocarbonspolybrominated biphenyl etherpolybrominated diphenyl etherpolychlorobiphenylpolynuclear aromatic hydrocarbonpsychiatric illnesspsychological disorderresponseresponse to therapyresponse to treatmentsadnesssexsocial stressessocial stressorsocio-economic positionsocioeconomic positionstressful experiencestressful life eventstressful life experiencestudent trainingtherapeutic responsetherapy responsetreatment responsetreatment responsivenesswhole genome
Description preview
SUMMARY
Major depressive disorder (MDD) is characterized by an extended episode of a persistent feeling of sadness or
a lack of interest in outside stimuli. It is among the most common mental illnesses, affecting 16.2% of individuals
in the US during their lifetime. MDD is a heterogeneous disorder with a variable clinical course, an…
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