grant
Research Project-2: Functionally Selective Ligands Targeting 5-HT7 Receptor as Potential Antinociceptive Agents
Organization FLORIDA AGRICULTURAL AND MECHANICAL UNIVLocation TALLAHASSEE, UNITED STATESPosted 1 Aug 1997Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY20251,2,3,4-Tetrahydroisoquinolines1,2,3,4-tetrahydro-isoquinolines5-HT7 receptor5-hydroxytryptamine-7 receptorAddressAffinityAgonistAlcohol abuseAnalgesia TestsAnalgesic AgentsAnalgesic DrugsAnalgesic PreparationAnalgesicsAnodynesAntinociceptive AgentsAntinociceptive DrugsBindingBioavailabilityBiological AvailabilityBrainBrain Nervous SystemBrain regionC-terminal Src kinaseCNS DiseasesCNS disorderCSK Protein KinaseCSK-srcCell Communication and SignalingCell SignalingCentral Nervous System DiseasesCentral Nervous System DisordersCharacteristicsCognitionCollaborationsDevelopmentDrug abuseDrugsDysfunctionEncephalonEnvironmentEtOH abuseEvaluationFunctional disorderG-ProteinsGTP-Binding ProteinsGTP-Regulatory ProteinsGeneral PopulationGeneral PublicGoalsGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsHealth Disparities ResearchHealth disparities related researchHep G2HepG2HepG2 cell lineHepatic CellsHepatic Parenchymal CellHepatocyteHydroxylationHyperalgesiaHyperalgesic SensationsIn VitroInflammatoryIntermediary MetabolismIntracellular Communication and SignalingLaboratoriesLeadLigandsLiteratureLiver CellsLytotoxicityMechanical StimulationMedicationMemoryMetabolicMetabolic ProcessesMetabolismMolecular InteractionNational Institutes of HealthNew AgentsNociception TestsOpiatesOpioidOpioid AnalgesicsOralPainPain AssessmentPain MeasurementPain measurePainfulPaperPathologyPathway interactionsPb elementPenetrationPermeabilityPharmaceutical PreparationsPharmacologic ActionsPharmacologyPhysiologic AvailabilityPhysiopathologyProtein-Tyrosine Kinase CYLPsychoactive AgentsPsychoactive CompoundPsychoactive DrugsPsychopharmaceuticalsPsychotropic DrugsR-Series Research ProjectsR01 MechanismR01 ProgramReceptor ProteinReportingResearch GrantsResearch Project GrantsResearch ProjectsRodentRodentiaRodents MammalsRoleSequence HomologySignal PathwaySignal TransductionSignal Transduction SystemsSignalingSleep DisordersSystemTestingTetrahydro-IsoquinolinesTetrahydroisoquinolinesTexasTherapeuticTyrosine-Protein Kinase CSKUnited States National Institutes of HealthUniversitiesabuse liabilityabuse of drugsabuse potentialabuses drugsaddictionaddictive disorderalcohol co-abusealcohol problemanalogantagonismantagonistantinociceptionantinociceptivearrestin Bbeta-arrestinbiological signal transductionc-src Kinasec-src Tyrosine Kinasecarboxy-terminal Src kinasechronic neuropathic painclinical candidatecytotoxiccytotoxicitydesigndesigningdetermine efficacydevelopmentaldrug/agenteffective therapyeffective treatmentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationenantiomerendogenous opiateendogenous opioidsethanol abuseevaluate efficacyevaluation/testingexamine efficacyfunctional grouphazardous alcohol usehealth disparities scienceheavy metal Pbheavy metal leadhyperalgiaimprovedin vivolead optimizationmetabolic profileneurochemicalneurochemistryneuropathic painopiate analgesiaopiate analgesicopiate pain medicationopiate pain relieveropioid analgesiaopioid anestheticopioid pain medicationopioid pain relieveropioid painkillerpain assaypain behaviorpain killerpain medicationpain relieverpain sensationpainful neuropathypainful sensationpainkillerpathophysiologypathwaypharmacokinetic characteristicpharmacologicpreventpreventingproblem alcohol useproblem drinkingproblematic alcohol consumptionproblematic alcohol useprocess optimizationprotein-tyrosine kinase C-terminal Src kinaseprotein-tyrosine kinase c-srcreceptorrecruitresponsescaffoldscaffoldingscreening programserotonin 7 receptorside effectsleep diseasessleep dysfunctionsleep illnesssleep problemsocial roletherapeutic evaluationtherapeutic testingβ-arrestin
Description preview
Project Summary/Abstract: Neuropathic pain is estimated in the general population to range between 3%
and 17%, and lacks an effective treatment, as most of the available treatments have only moderate efficacy
and present significant side effects including addiction that limit their use. Therefore, other therapeutic
approaches are needed to replace…
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