grant
Research Project 2: Biomaterial-driven CAR T cell generation for treatment of GBM
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 5 Mar 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026AbscissionAcuteAlginatesAnimal ModelAnimal Models and Related StudiesB7-H3B7H3Biocompatible MaterialsBiomaterialsBlood - brain barrier anatomyBlood-Brain BarrierBody TissuesBrainBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TumorsCAR T cell therapyCAR T cellsCAR T therapyCAR modified T cellsCAR-TCAR-TsCD276CD276 geneCancersCell BodyCellsCessation of lifeCirculationClinicClinicalClinical DataClinical TrialsComplexConsumptionCuesDataDeathDevelopmentDoseEffectivenessEncephalonEngineeringEnsureExcisionExtirpationFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryForeign BodiesGenerationsGlioblastomaGoalsGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaHemato-Encephalic BarrierIV InfusionImmuneImmune responseImmune systemImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImplantIn SituInfiltrationInfusionInfusion proceduresIntrasurgical Resection CavityIntravenous infusion proceduresLiquid substanceMalignant NeoplasmsMalignant TumorMeasuresMediatingMethodsMiceMice MammalsModalityModelingMultiple MyelomaMurineMusNK T cellNK cell immune therapyNK cell immunotherapyNK cell therapyNK cell treatmentNK cell-based immune therapyNK cell-based immunotherapyNK cell-based therapyNK cell-based treatmentNK cellular immunotherapyNK cellular therapyNK immunotherapyNK therapyNK treatmentNKT cellNatural Killer Cell ImmunotherapyNatural Killer T cellNon-Hodgkin's LymphomaNonhodgkins LymphomaOperative ProceduresOperative Surgical ProceduresOutcomePatientsPhenotypePhysiologicPhysiologicalPlasma-Cell MyelomaProceduresProcessProductionPropertyR-Series Research ProjectsR01 MechanismR01 ProgramRNA SeqRNA sequencingRNAseqRecurrenceRecurrentRemovalResearch GrantsResearch Project GrantsResearch ProjectsResection CavitySafetySightSiteSolid NeoplasmSolid TumorSpeedSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSurgically-Created Cystic Resection CavitySurgically-Created Resection CavityT cells for CART-Cell Receptor InteractionT-CellsT-LymphocyteTCR ActivationTCR InteractionTechnologyTestingTherapeuticTimeTissuesTranslatingVirusVisionWorkaggressive therapyaggressive treatmentbiocompatibilitybiological materialbiomaterial compatibilitybloodbrain barriercancer carecancer microenvironmentcell transductioncellular transductionchimeric antigen T cell receptorchimeric antigen receptorchimeric antigen receptor (CAR) T cell therapychimeric antigen receptor (CAR) T cellschimeric antigen receptor Tchimeric antigen receptor T cell therapychimeric antigen receptor T cellschimeric antigen receptor T therapychimeric antigen receptor fusion protein T-cellschimeric antigen receptor modified T cellsclinical efficacyclinical translationclinically translatablecostcytokinedesigndesigningdevelopmentaldraining lymph nodeengineered T cellsexperienceflow cytophotometryfluidgenetically engineered T-cellsglioblastoma multiformehost responseimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunogenicityimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimplantationimprovedin vivoinfusionsinnovateinnovationinnovativeinsightinterestintravenous infusionliquidmalignancymanufacturemanufacturing processmodel of animalmyelomamyelomatosisnatural killer T lymphocytenatural killer cell based immune therapynatural killer cell based immunotherapynatural killer cell therapynatural killer cell treatmentnatural killer cell-based therapynatural killer cellular therapynatural killer therapyneoplasm/cancernew approachesnon-Hodgkins diseasenovel approachesnovel strategiesnovel strategyregional lymph noderesectionresponsescaffoldscaffoldingspongioblastoma multiformestandard of caresuccesssurgerythymus derived lymphocytetranscriptome sequencingtranscriptomic sequencingtransduced cellstransgenic T- cellstumortumor microenvironmenttumors in the brainvisual function
Description preview
ABSTRACT – RESEARCH PROJECT 2
Glioblastoma multiforme (GBM) is a lethal brain tumor with a median survival of less than two years, despite
aggressive treatment. The recent success of CAR T cell therapy against Non-Hodgkin’s Lymphomas and Multi-
ple Myeloma has sparked significant interest in its potential for GBM. Although clinical trials have…
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