grant
Research Project 2: Antigen design and immunological evaluation
Organization ALBERT EINSTEIN COLLEGE OF MEDICINELocation BRONX, UNITED STATESPosted 1 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025Amino AcidsAndes VirusAnimal ModelAnimal Models and Related StudiesAnimalsAntibody Binding SitesAntibody RepertoireAntibody ResponseAntibody SpecificityAntigenic DeterminantsAntigensAssayB blood cellsB cellB cellsB-Cell SubsetsB-CellsB-Lymphocyte SubsetsB-LymphocytesB-cellB-cell receptor repertoire sequencingB-cell receptor sequencingBCR repertoire sequencingBCR seqBCR sequencingBCRseqBindingBinding DeterminantsBioassayBiological AssayBody TissuesBunyavirusCell BodyCell FunctionCell Mediated ImmunologyCell PhysiologyCell ProcessCell Surface AntigensCell-Mediated ImmunityCell-Mediated Lympholytic CellsCellsCellular FunctionCellular ImmunityCellular PhysiologyCellular ProcessClinical Treatment MoabComplexCongo VirusCongo hemorrhagic fever virusCrimean Hemorrhagic Fever VirusCrimean-Congo Hemorrhagic Fever VirusCrimean-Congo hemorrhagic fever orthonairovirusCrystallographiesCrystallographyCytolytic T-CellCytotoxic T CellCytotoxic T-LymphocytesDistantELISAEngineeringEnvironmentEnzyme-Linked Immunosorbent AssayEpidemic Hemorrhagic Fever VirusEpitopesEvaluationFamilyFour Corners VirusFour Corners hantavirusGoalsHantaan virusHantavirusHeadHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHemorrhagic Nephroso-Nephritis VirusHumoral ImmunitiesImmuneImmune responseImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunological Surface MarkersImmunologicallyImmunologicsImmunotherapeutic agentInducer CellsInducer T-LymphocytesInvestigationKnowledgeKorean Hemorrhagic Fever VirusLeadM proteinMachine LearningMapsMediatingMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMethodologyMiceMice MammalsMolecular InteractionMonoclonal AntibodiesMuerto Canyon VirusMurineMusNairovirusNipah VirusNipah henipavirusOrthobunyavirusOrthohantavirusesOrthonairovirusParamyxoviridaeParamyxovirusParatopesPb elementPeptidesPeripheralPositionPositioning AttributeProcessProductionProtein EngineeringProteinsR-Series Research ProjectsR01 MechanismR01 ProgramRNA vaccineRNA-based vaccineRecombinantsReference StandardsResearch GrantsResearch Project GrantsResearch ProjectsResearch ResourcesResourcesRoleSamplingSin Nombre hantavirusSin Nombre virusSplenocyteStructureSubcellular ProcessSurfaceSurface AntigensSurface ProteinsT cell receptor repertoire sequencingT cell receptor sequencingT cell responseT memory cellT-Cell DepletionT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT-cell depletion therapyT-cell diversityT-lymphocyte depletion therapyTCR repertoire sequencingTCR sequencingTCR-seqTCRseqTissuesUpregulationVaccinatedVaccinationVaccine AntigenVaccine DesignVaccinesViralViral AntigensViral DiseasesViral VaccinesVirusVirus DiseasesWorkaminoacidanimal efficacyantibody combining siteantibody-based immunitycomparativecytokinedesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccineefficacy studyefficacy testingenzyme linked immunoassayexperiencegenetic protein engineeringheavy metal Pbheavy metal leadhost responseimmune drugsimmune system responseimmune-based therapeuticsimmunogenimmunogenicityimmunologic therapeuticsimmunoresponseimmunotherapeuticsimmunotherapy agentin vivokiller T celllead candidatemAbsmRNA vaccinemRNA-based vaccinemachine based learningmemory T lymphocytemodel of animalmonoclonal Absmultiple myeloma M Proteinnovelpandemic concernpandemic potentialpandemic riskpandemic threatpathogenic viruspolyclonal antibodyprotective efficacyprotein complexprotein designprototyperesident memory T cellsocial rolestructural biologythymus derived lymphocytetissue resident memory T cellvaccine developmentvaccine efficacyvaccine platformvaccine strategyviral infectionviral pathogenvirus antigenvirus infectionvirus pathogenvirus-induced disease
Description preview
In Project 2 (P2) we will use cutting-edge antigen engineering to refine vaccine antigen design strategies through
iterative assessments of immunogenicity and protective efficacy to generate optimized vaccine immunogens
against nairo-, hanta-, and paramyxoviruses. Our approach will establish a protective antigen engineering
blueprint for emerging…
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