grant
Research Project 1 - Allerton
Organization LSU PENNINGTON BIOMEDICAL RESEARCH CTRLocation BATON ROUGE, UNITED STATESPosted 1 Mar 2020Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY20253-MP-sulfurtransferase3-Mercaptopyruvate sulfurtransferaseAnimal ModelAnimal Models and Related StudiesAnimalsBioavailabilityBioenergeticsBiological AvailabilityBlood PlasmaBlood VesselsBody TissuesBranched-Chain Amino AcidsCatabolismCell Communication and SignalingCell SignalingCommon Rat StrainsCystathionaseCystathionine gamma-LyaseCysteine DesulfhydraseCystine DesulfhydraseCystine DesulfohydrolaseDataDevelopmentDiabetes MellitusDiastolic heart failureDiseaseDisorderDown-RegulationEndothelial CellsEndotheliumEnzyme GeneEnzymesExerciseExercise ToleranceFatsFatty acid glycerol estersFiberFoundationsGasesGene TranscriptionGeneticGenetic TranscriptionGoalsH2O2HF with preserved ejection fractionHFpEFHeart failureHomoserine DeaminaseHomoserine DehydrataseHospital AdmissionHospitalizationHumanHydrogen PeroxideHydrogen SulfideHydroperoxideHypertensionImpairmentIntermediary MetabolismIntracellular Communication and SignalingInvestigationIsotopesLeadMeasuresMetabolicMetabolic ProcessesMetabolic dysfunctionMetabolismMethodsMiceMice MammalsMitochondriaModelingModern ManMurineMusMuscle CellsMuscle FibersMuscle MitochondriaMuscle functionMutant Strains MiceMyocytesMyotubesObesityOxygen ConsumptionPathway interactionsPatientsPb elementPerformancePerfusionPermeabilityPersonsPhasePhysiologicPhysiologic AvailabilityPhysiologicalPlasmaPlasma SerumR-Series Research ProjectsR01 MechanismR01 ProgramRNA ExpressionRatRats MammalsRattusResearch GrantsResearch Project GrantsResearch ProjectsResolutionRespirationReticuloendothelial System, Serum, PlasmaRhabdomyocyteRodentRodent ModelRodentiaRodents MammalsRoleSarcosomesSignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSkeletal FiberSkeletal MuscleSkeletal Muscle CellSkeletal Muscle FiberSkeletal MyocytesSourceSpirometrySupplementationSymptom BurdenSymptomsTechniquesTestingTissuesTranscriptionUnited StatesVascular Hypertensive DiseaseVascular Hypertensive DisorderVoluntary Muscleadiposityamino acid metabolismbeta-mercaptopyruvate sulfurtransferasebiological signal transductionbranched amino acidscardiac failurecardiometaboliccardiometabolismcardiovascular healthco-morbidco-morbiditycomorbiditycorpulencedetection methoddetection proceduredetection techniquedevelopmentaldiabetesenzyme activityexercise capacityexercise intoleranceexperiencefatty acid oxidationgain of functiongamma-Cystathionaseheart failure with preserved ejection fractionheart failure with preserved systolic functionheavy metal Pbheavy metal leadhigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderhypoperfusionimprovedin vivomitochondrialmitochondrial dysfunctionmodel of animalmortalitymouse mutantmuscle metabolismnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetoverexpressoverexpressionoxidationpathwaypreserved ejection fraction heart failureprognostic of overall survivalprognostic of survivalresolutionsrespiratory mechanismresponseskeletal muscle atrophyskeletal muscle breakdownskeletal muscle lossskeletal muscle metabolismskeletal muscle protein lossskeletal muscle protein metabolismskeletal muscle wastingsocial rolesulfating enzymesulfurtransferasesurvival outcomesurvival prognosistranssulfurasevascular
Description preview
Project Summary
Heart failure with preserved ejection fraction (HFpEF) will soon become the predominant form of heart failure.
Patients with cardiometabolic HFpEF have multiple co-morbidities including obesity, hypertension, and diabetes.
The primary symptom of HFpEF is exercise intolerance. Skeletal muscle metabolic dysfunction and
hypoperfusion…
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