grant
Reprogramming of tissue structural cells by cutaneous CD4+ T cells
Organization BENAROYA RESEARCH INST AT VIRGINIA MASONLocation SEATTLE, UNITED STATESPosted 19 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026Actinic RaysAddressAtopic DermatitisAtopic EczemaAtopic NeurodermatitisB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBehaviorBody TissuesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCell BodyCell Communication and SignalingCell Culture SystemCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessChemicalsCutaneousCutaneous DisorderDermatosesDevelopmentDiseaseDisorderDisseminated NeurodermatitisDrug TargetingDysfunctionEndothelial CellsEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFibroblastsFibrosisFunctional disorderGene TranscriptionGenetic TranscriptionHost DefenseHumanImmuneImmunesIn VitroInfectionInflammationInflammatoryInflammatory ResponseIntracellular Communication and SignalingIrritantsItchingKnowledgeLinkMediatorMemoryModalityModern ManModificationMonitorOrganismPathway interactionsPatientsPhysiopathologyPre-Clinical ModelPreclinical ModelsProcessPruritic DisorderPruritisPruritusPsoriasisRNA ExpressionResolutionSamplingSignal TransductionSignal Transduction SystemsSignalingSiteSkinSkin DiseasesSkin Diseases and ManifestationsStimulusSubcellular ProcessSystemT cell responseT-CellsT-LymphocyteT4 CellsT4 LymphocytesTherapeuticTissue SampleTissuesTranscriptionTraumaUV lightUV radiationUV raysUltraviolet RaysVascular Endothelial Cellallergic dermatitisallergic eczemabiological signal transductioncell behaviorcellular behaviorcutaneous barriercutaneous diseasecytokinedermal barrierdermal diseasedermal disorderdevelopmentalepidermal barrierepigeneticallyhumanized micehumanized mousein vivoinnovateinnovationinnovativeitch sensationkeratinocyteliving systemmicrobialmouse modelmurine modelnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathogenpathophysiologypathwaypre-clinicalpreclinicalpreventpreventingprogramspsoriasiformpsoriaticresolutionsresponseskin barrierskin disordertargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthymus derived lymphocytetissue repairtissue-repair responsesultra violet lightultra violet radiationultra violet raysultraviolet lightultraviolet radiation
Description preview
Project Summary/Abstract
Although long thought to be a unique feature of adaptive cells such as T and B cells, it is now clear that tissue
structural cells can also harbor ‘memory’ of prior inflammatory responses in the form of stable epigenetic
modifications that alter their transcriptional potential and behavior following subsequent tissue…
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