grant
Reproductive tract organ development and differentiation
Organization UNIVERSITY OF TX MD ANDERSON CAN CTRLocation HOUSTON, UNITED STATESPosted 19 Jul 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025Anti-OncogenesAntioncogenesBiologyCancer Suppressor GenesCancersCannot achieve a pregnancyCausalityCompetenceComplexDefectDevelopmentDifferences of sex developmentDifficulty conceivingDiseaseDisorderDuct EpitheliumDuctal EpitheliumDuctus DeferensEmbryoEmbryonicEmerogenesEndocrine Gland SecretionEpididymisEpitheliumEtiologyFallopian TubesFemaleFetal KidneyGene ExpressionGene TranscriptionGenesGenetic TranscriptionGonadal HormonesHigh-Risk PregnancyHormone ResponsiveHormonesHornsHumanInfertilityKnowledgeLeadMalignant NeoplasmsMalignant TumorMammaliaMammalian OviductsMammalsMediatingMesenchymal Progenitor CellMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsMesenchymasMesenchymeMesonephric DuctMiceMice MammalsMiscarriageModern ManMolecularMorphogenesisMorphologyMuellerian inhibiting hormoneMullerian DuctsMullerian-inhibiting factorMurineMusOnco-Suppressor GenesOncogenes-Tumor SuppressorsOrganOvaryParamesonephric DuctPathway interactionsPb elementPhenotypeProcessProtein SecretionRNA ExpressionRecessive OncogenesRegulatory ElementReporter GenesReproductionSalpinxSeminal SacsSeminal VesiclesSexual DevelopmentSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSiteSpontaneous abortionStructure of mesonephric ductStructure of paramesonephric ductSystemTesticlesTestisTestosteroneTherapeutic HormoneTherapeutic TestosteroneTrans-TestosteroneTranscriptionTumor Suppressing GenesTumor Suppressor GenesUrogenital SinusUterine TubesUterusVaginaVariantVariationVas DeferensVas deferens structureWAGRWNT7AWNT7A geneWT1WT1 Gene ProductWT1 ProteinWT1 geneWT33Wilms Tumor 1Wilms tumor suppressor WT1Wingless-Type MMTV Integration Site Family, Member 7AWolffian Ductanti-mullerian factoranti-mullerian hormonecausationdevelopmentaldisease causationdisorder of sexual developmentexperimentexperimental researchexperimental studyexperimentsfemale genital tractfemale reproductive tractfertility cessationfertility lossfetalgenital tractheavy metal Pbheavy metal leadhormonal signalshormone signalsinfertileinsightmalemalformationmalignancymesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsmigrationmorphogenetic processmullerian inhibiting substancemullerian regression factormullerian-inhibiting hormonemullerian-inhibitory substanceneoplasm/canceroncosuppressor geneorgan developmentorgan growthoviductpathwayreceptor bindingreceptor boundreproductive organreproductive tractsexsex developmentsex development disordertissue progenitortissue specific progenitor cellstissue specific stem cellstissue stem cellswombwomen's genital tractwomen's reproductive tract♀♂
Description preview
Project Summary
Mammalian embryos have the potential to develop both male and female reproductive tract organs. However,
they typically only differentiate one sex type depending on the presence or absence of fetal gonadal hormones.
Two paired epithelial ducts form within the mesonephroi (fetal kidneys) in both genetically male and female
embryos.…
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