grant
Replication fork dynamics and repair by Rad51 paralogs after DNA alkylation
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Sept 2019Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY2026ATP phosphohydrolaseATPaseAddressAdenosine TriphosphataseAlkylating AgentsAlkylationAlkylatorsAnemiaAntigen-Presenting CellsAssayBaker's YeastBindingBioassayBiochemicalBiological AssayBreast CancerBrewer's YeastBudding YeastBypassCRISPRCRISPR/Cas systemCancersCause of DeathCell BodyCell Death InductionCellsCessation of lifeChIP SequencingChIP-seqChIPseqClustered Regularly Interspaced Short Palindromic RepeatsComplexCongenital PancytopeniaDNADNA AlkylationDNA DamageDNA Damage RepairDNA HelicasesDNA InjuryDNA RecombinationDNA RepairDNA Repair GeneDNA Repair Protein XRCC2DNA SequenceDNA Unwinding ProteinsDNA lesionDNA mutationDNA repair proteinDNA replication forkDNA seqDNA sequencingDNA unwinding enzymeDNAseqDeathDeoxyribonucleic AcidDevelopmentEndomycetalesEnvironmentEnvironmental ToxinEukaryotaEukaryoteExhibitsExposure toFanconi AnemiaFanconi PanmyelopathyFanconi dysplasiaFanconi's AnemiaFilamentGenesGeneticGenetic ChangeGenetic RecombinationGenetic defectGenetic mutationGenome InstabilityGenomic InstabilityGerm LinesHeritabilityHumanHuman Cell LineIn VitroIndividualInduced DNA AlterationInduced MutationInduced Sequence AlterationIndustrializationInvadedKnock-outKnockoutLearningLesionMalignant Breast NeoplasmMalignant CellMalignant NeoplasmsMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant TumorMalignant Tumor of the OvaryMalignant neoplasm of ovaryMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMediatorMethyl MesilateMethyl MesylateMethyl MethanesulfonateMethyl MethylenesulfonateMethylmesilateMethylmethane SulfonateModelingModern ManMolecular InteractionMutateMutationNatureNucleoproteinsORC proteinOncogenesisOutcomeOvary CancerPathway interactionsPatientsPredispositionPrimary Erythroid HypoplasiaProcessProteinsRAD51 proteinRAD51CRAD51C geneRad51 recombinaseReactionRecombinantsRecombinationRegulationRepair ComplexReplication OriginRiskRoleS PeriodS cerevisiaeS phaseS. cerevisiaeSEQ-ANSaccharomyces cerevisiaeSaccharomycetalesSequence AnalysesSequence AnalysisSingle-Stranded DNASiteSomatic MutationSourceSpecificityStructureSusceptibilitySynthesis PeriodSynthesis PhaseTestingToxic Environmental AgentsToxic Environmental SubstancesTravelUnited StatesUnscheduled DNA SynthesisVariantVariationWorkX-Ray Repair Cross Complementing Protein 2X-Ray Repair Cross Complementing Protein 3X-Ray Repair, Comlementing Defective, In Chinese Hamster, 3XRCC2XRCC2 geneXRCC3XRCC3 geneYeastsaccessory cellautonomously replicating sequencecancer cellcancer predispositionchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcongenital aplastic anemiadevelopmentalenvironmental toxicantgenome mutationgenome wide screenhelicasehomologous recombinationin vivoinsightmalignancymalignant breast tumormembermethyl ester Methanesulfonic acidmutantneoplasm/cancernovelori Regionorigin recognition complexovarian cancerparalogparalogous genepathwaypreventpreventingprotein complexrecruitrepairrepairedreplication forkreplication stresssingle moleculesocial rolesomatic variantssDNAtumorigenesis
Description preview
Project Summary
Misrepair of DNA damage is a hallmark of cancer. We discovered that the budding yeast Shu complex is a
conserved regulator of DNA repair through a central role in Rad51 regulation. Rad51 functions during the high
fidelity homologous recombination pathway to find and invade a homologous template for repair and also
during…
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