grant
Repetitive sequences drive genome variation and plasticity
Organization UNIVERSITY OF CONNECTICUT SCH OF MED/DNTLocation FARMINGTON, UNITED STATESPosted 1 Sept 2019Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY2025AssayBasal Transcription FactorBasal transcription factor genesBase PairingBinding SitesBioassayBiological AssayCancersCombining SiteComputational BiologyDNA RearrangementDNA Transposable ElementsDiseaseDisorderEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEventEvolutionGene Action RegulationGene DuplicationGene Expression RegulationGene RearrangementGene RegulationGene Regulation ProcessGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGenetic TranscriptionGenomeGenome InstabilityGenome StabilityGenomic InstabilityGenomic StabilityGenomicsGoalsHealthHumanHuman GenomeIndividualInvestigationInvestigatorsKnowledgeMalignant NeoplasmsMalignant TumorMediatingMiceMice MammalsModern ManMolecularMosaicismMurineMusPlayPopulationPostbaccalaureatePromoter RegionsPromotor RegionsRNA ExpressionReactive SiteRepetitive ElementRepetitive RegionsRepetitive SequenceReporterResearchResearch PersonnelResearchersRoleTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransposable ElementsVariantVariationWorkYeastscareercomputer biologyepigeneticallygenetic promoter elementgenetic promoter sequencegenomic variationglobal gene expressionglobal transcription profilegraduate studenthuman whole genomemalignancymammalian genomemosaic diseasesmosaic disordersmouse genomeneoplasm/cancerpostbacpostbaccprogramspromoter sequencesocial rolestructural mutationstructural variantstructural variationsummer studenttooltranscription factortranscriptome
Description preview
ABSTRACT
The mechanisms by which mammalian genomes maintain stability through generations and divisions are
important, and de-regulation of these cellular programs can lead to somatic mosaicism, disease, and cancer.
Many multicellular eukaryotic genomes are replete with repeats that include ancient repeat mobility events,
actively mobilizing…
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