grant
Renal Denervation to Treat Polycystic Kidney Disease: Mechanisms and Mediators
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Nov 2024Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY20260-11 years old21+ years old4 year old4 years of age8-Arg-vasopressin-receptorADPKDARPKDAVPR2AVPR2 geneAblationAddressAdultAdult HumanAdult Polycystic Kidney DiseaseAgeAntidiuretic HormoneArginine VasopressinArgipressinArteriesAutosomal Dominant Polycystic KidneyAutosomal Dominant Polycystic Kidney DiseaseAutosomal Recessive Polycystic KidneyAutosomal Recessive Polycystic Kidney DiseaseBilateralBlood Plasma VolumeBody TissuesCardiovascular DiseasesCathetersCell Communication and SignalingCell Growth in NumberCell MultiplicationCell ProliferationCell SignalingCellular ProliferationChildChild YouthChildren (0-21)ChronicClinicalCommon Rat StrainsContralateralCystCystic kidneyDI1DataDenervationDialysisDialysis procedureDiseaseDisease ProgressionDisorderDominant Polycystic Kidney DiseaseESKDESRDEnd stage renal failureEnd-Stage Kidney DiseaseEnd-Stage Renal DiseaseFDA approvedFutureGenesHereditaryHypertensionHypothalamic structureHypothalamusInflammationInflammatoryInheritedInterventionIntracellular Communication and SignalingInvestigationInvestigatorsKidneyKidney CystKidney DiseasesKidney GraftingKidney TransplantationKidney TransplantsKidney Urinary SystemMediatingMediatorModalityModelingMolecularNephropathyNerveNerve Impulse TransmissionNerve TransmissionNeuronal TransmissionOsmolalitiesPKD1 proteinPKD2 proteinPathogenesisPathogenicityPathway interactionsPatientsPhasePlasma VolumePolycystic KidneyPolycystic Kidney DiseasesPolydipsiaPolyuriaPre-Clinical ModelPreclinical ModelsPrincipal InvestigatorProliferatingPublishingQOLQuality of lifeRatRats MammalsRattusRecessive Polycystic Kidney DiseaseRegulationRenal CellRenal CystRenal DiseaseRenal GraftingRenal TransplantationRenal TransplantsRenal functionReportingResearchResearch PersonnelResearch ProposalsResearchersRoleSensorySignal TransductionSignal Transduction SystemsSignalingStimulusSymptomsTechniquesTestingTherapeuticTimeTissuesV2RVascular Hypertensive DiseaseVascular Hypertensive DisorderVasopressin-Neurophysin II-CopeptinVasopressinsadulthoodafferent nerveage 4age 4 yearsagesantagonismantagonistarginine vasopressin receptorargipressin receptorautosomeaxon signalingaxon-glial signalingaxonal signalingbeta-Hypophaminebiological signal transductioncardiovascular disordercytokinedialysis therapyfour year oldfour years of ageglia signalingglial signalinghigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderhypothalamicinnervationinnovateinnovationinnovativekidney cellkidney disorderkidney dysfunctionkidney functionkidney txkidsloss of function mutationmouse modelmurine modelnerve signalingnerve supplyneuralneural signalingneuronal signalingneurotransmissionnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathwaypatient populationpcy proteinpharmacologicpolycystic breakpoint proteinpolycystic kidney disease 1 proteinpolycystic kidney disease 2 proteinpolycystin 1polycystin 2preservationpressureprophylacticrenalrenal disorderrenal dysfunctionresponsesensory nervesocial rolesuccesstolvaptanyoungster
Description preview
Polycystic kidney disease (PKD), both autosomal dominant (AD) and autosomal recessive (AR) forms, remains
the leading cause of inheritable kidney disease in adults and children throughout the US as well as worldwide.
Though the pathogenesis of renal cyst formation is understood to be driven primarily by a loss-of-function
mutation in the…
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