grant
Regulatory T cells maintain immune homeostasis through translation control
Organization BENAROYA RESEARCH INST AT VIRGINIA MASONLocation SEATTLE, UNITED STATESPosted 13 Dec 2023Deadline 31 Oct 2028
NIHUS FederalResearch GrantFY2026AcuteAntigen-Presenting CellsAutoantigensAutoimmune DiseasesAutoimmune StatusAutoimmunityAutologous AntigensAutomobile DrivingAutoregulationBasal Transcription FactorBasal transcription factor genesBody TissuesBrittle Diabetes MellitusCD152CD152 AntigenCD152 GeneCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCSIFCSIF-10CTLA 4CTLA-4 GeneCTLA4CTLA4 geneCTLA4-TMCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellular FunctionCellular PhysiologyCellular ProcessCellular biologyCytokine Synthesis Inhibitory FactorCytotoxic T-Lymphocyte Protein 4Cytotoxic T-Lymphocyte-Associated Antigen 4Cytotoxic T-Lymphocyte-Associated Protein 4Cytotoxic T-Lymphocyte-Associated Serine Esterase-4DNA mutationDataDevelopmentDisseminated SclerosisDropsDysfunctionEragrostisFOXP3FOXP3 geneFailureForkhead Box P3Functional disorderGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGoalsHomeostasisHumanIDDMIL-10IL10IL10AIPEXImmuneImmune responseImmune systemImmunesImmunodysregulation polyendocrinopathy enteropathy X-linked syndromeInflammationInsulin-Dependent Diabetes MellitusInterleukin 10 PrecursorInterleukin-10Intracellular Communication and SignalingJM2Juvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusMaintenanceMediatingMessenger RNAMiceMice MammalsModelingModern ManMolecularMultiple SclerosisMurineMusMutationNatureNon-Polyadenylated RNAPD 1PD-1PD1Pathway interactionsPhysiological HomeostasisPhysiopathologyPolyribosomesPolysomesPost-Transcriptional ControlPost-Transcriptional RegulationProcessProliferatingProtein BiosynthesisProteinsRNARNA ExpressionRNA Gene ProductsRNA-Binding ProteinsReceptor ProteinRegulationRegulatory T-LymphocyteRibonucleic AcidRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRibosomesRoleSCURFINSelf-AntigensSignal TransductionSignal Transduction SystemsSignalingSubcellular ProcessSudden-Onset Diabetes MellitusSyndromeT cell regulationT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT1 DMT1 diabetesT1DT1DMT4 CellsT4 LymphocytesTeffTeff cellTestingTherapeutic InterventionTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranslatingTranslational InhibitionTranslational RepressionTranslationsTregType 1 Diabetes MellitusType 1 diabetesType I Diabetes Mellitusaccessory cellautoimmune conditionautoimmune disorderautoimmunity diseaseautoreactive T cellbiological signal transductioncell biologycytokinecytotoxic T-lymphocyte antigen 4developmentaldrivingeffector T cellexperimentexperimental researchexperimental studyexperimentsgenome mutationhost responseimmune system responseimmunopathologyimmunoresponseinsightinsular sclerosisinsulin dependent diabetesinsulin dependent type 1intervention therapyjuvenile diabetesjuvenile diabetes mellitusketosis prone diabetesmRNAmRNA Translationnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathogenpathophysiologypathwayperipheral tolerancepost-transcriptional gene regulationprogrammed cell death 1programmed cell death protein 1programmed death 1protein synthesisreceptorregulatory T-cellsself-reactive T cellsle2social rolesystemic lupus erythematosus susceptibility 2therapeutic targetthymus derived lymphocytetranscription factortranslationtranslatometype I diabetestype one diabetes
Description preview
PROJECT SUMMARY
The immune system needs to distinguish between self and non-self, and between pathogen and
commensal. In part it does through the function of regulatory T cells, a specialized subset of CD4 T cells that
are critical for maintaining immune homeostasis, as well as maintaining tolerance toward self-antigens. Their
importance to…
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