grant
Regulation of Vascular Calcification by Adventitial Endothelial Cells
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 1 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY202521+ years oldAPOEASCVDAccelerationAdultAdult HumanAdventitiaAffectAgeAge YearsAnimal ModelAnimal Models and Related StudiesAortaApo-EApoE proteinApolipoprotein EArterial Fatty StreakArteriesAtheromaAtheromatousAtheromatous degenerationAtheromatous plaqueAtherosclerosisAtherosclerotic Cardiovascular DiseaseBlood VesselsBone DevelopmentBone FormationCD31CalcifiedCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCartilageCartilaginous TissueCell Communication and SignalingCell LineCell SignalingCellLineCellular biologyChondrocytesDataDepositDepositionDevelopmentDevelopment PlansDiseaseDisorderDrosophila Homolog of NOTCH 1Endothelial CellsEndotheliumExhibitsExpression SignatureFluorescence Light MicroscopyFluorescence MicroscopyFoundationsGene ExpressionGene Expression ProfileGene TargetingGenetic MarkersGlycoproteinsHeart VascularHumanIntracellular Communication and SignalingK-AwardsK-Series Research Career ProgramsKO miceKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeLightMedicalMentorsMesenchymalMiceMice MammalsMineralsModelingModern ManMolecularMolecular FingerprintingMolecular ProfilingMorbidityMorbidity - disease rateMurineMusNOTCH1NOTCH1 geneNull MouseOsteogenesisPECAM1PECAM1 genePathologicPathologic ProcessesPathological ProcessesPathologyPatientsPatternPhenotypePhotoradiationPhysiciansPopulationProgenitor CellsRNA SeqRNA sequencingRNAseqReceptor ProteinRegulationReportingResearchResearch Career ProgramScientistSeveritiesSignal TransductionSignal Transduction SystemsSignalingStrains Cell LinesSupporting CellTAN1TherapeuticTranslocation-Associated NOTCH HomologTunica AdventitiaVascular DiseasesVascular DisorderVascular Endothelial CellVascular calcificationX-ray microtomographyXray microtomographyadulthoodagesangiogenesisarterial stiffeningarterial stiffnessartery stiffeningartery stiffnessatheromatosisatherosclerosis plaqueatherosclerotic diseaseatherosclerotic lesionsatherosclerotic plaqueatherosclerotic vascular diseasebiological signal transductionbiomineralizationblood vessel disorderbonebone tissue formationcalcificationcardiovascular riskcardiovascular risk factorcareercareer developmentcell biologycirculatory systemcultured cell linedevelopmentalendomucinendothelial-specific sialomucingene biomarkergene expression biomarkergene expression patterngene expression signaturegene markergene signature biomarkergenetic biomarkerinsightmatrix Gla proteinmatrix gamma-carboxyglutamic acid proteinmicro CTmicro computed tomographymicroCTmicroscope imagingmicroscopic imagingmicroscopy imagingmicrotomographymodel of animalmolecular profilemolecular signaturemortalitynew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynotchnotch proteinnotch receptorsnovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachosteoblast progenitorosteoblast stem cellosteogenicosteogenic progenitorosteogenic stem cellosteoprogenitorosteoprogenitor cellplaques in atherosclerosispreventpreventingreceptorscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingstem cellstranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencingvascularvascular contributionsvascular dysfunctionvasculopathy
Description preview
PROJECT SUMMARY/ABSTRACT
Vascular calcification affects ~60% of adults over 60 years of age and is frequently seen in patients with
atherosclerosis. Atherosclerotic calcification is an independent risk factor for cardiovascular morbidity and
mortality. Despite decades of research, no medical therapy has been convincingly established to prevent or…
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