grant
Regulation of translation initiation by the epitranscriptome
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 1 Aug 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY20255' Untranslated Regions5'UTRAffectAutoregulationAwardBiological FunctionBiological ProcessBiologyCell BodyCellsCellular biologyChemicalsCodeCoding SystemCollectionDNADeoxyribonucleic AcidDiseaseDisorderEnzyme GeneEnzymesEukaryotic CellExposure toGene ExpressionGeneticGenomeGoalsHealthHomeostasisHumanInitiation CodonInitiator CodonModern ManModificationNon-Polyadenylated RNANucleic Acid Biochemistry, RNA - Ribonucleic AcidORFsOpen Reading FramesOrganismPhysiologicPhysiologicalPhysiological HomeostasisProcessProtein BiosynthesisProtein Coding RegionProteinsPublishingRNARNA BiochemistryRNA Gene ProductsRNA Nucleic Acid BiochemistryResearchRibonucleic AcidRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisSiteStart CodonStressTranscriptTranslation InitiationTranslational RegulationTranslationscell biologyepitranscriptomehuman diseaseinsightliving systemmRNA Leader SequencesmRNA Translationprogramsprotein synthesissynthetic biologytechnological innovationtranscriptomicstranslationtranslation factor
Description preview
Project Summary/Abstract
My research program investigates how the epitranscriptome regulates protein synthesis and how this interplay
affects cell fate decisions under normal homeostasis and stress conditions. The epitranscriptome is the collection
of more than 150 chemical modifications that occur on RNA molecules and influence all steps of gene…
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