grant
Regulation of TLR trafficking for proper self versus non-self discrimination
Organization UNIVERSITY OF CALIFORNIA BERKELEYLocation BERKELEY, UNITED STATESPosted 1 Feb 2008Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2026AlanineAtrophic ArthritisAutoimmuneAutoimmune DiseasesAutoimmune StatusAutoimmunityBiological FunctionBiological ProcessCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCell BodyCellsCellular biologyChaperoneCodeCoding SystemCognitive DiscriminationDNADNA mutationDeoxyribonucleic AcidDiscriminationDiseaseDisorderEndosomesExtracellular SpaceFamilyFundingGenesGenetic ChangeGenetic defectGenetic mutationGenetics-MutagenesisGoalsGrantHealthHumanImmunologic ReceptorsImmunological ReceptorsIndividualInnate Immune SystemIntercellular SpaceKI miceKnock-in MouseLupusLysosomesMediatingMiceMice MammalsMicrobeModelingModern ManMolecularMolecular ChaperonesMurineMusMutagenesisMutagenesis Molecular BiologyMutationNon-Polyadenylated RNANucleic AcidsPathway interactionsPatientsPlayPositionPositioning AttributePsoriasisPsoriasis ArthropathicaPsoriatic ArthritisRNARNA Gene ProductsReceptor ProteinReceptosomesRegulationResearchRheumatoid ArthritisRibonucleic AcidRiskRoleScanningTLR proteinTLR8TLR8 geneTestingToll-Like Receptor 8Toll-Like Receptor Family GeneToll-like receptorsVariantVariationWorkautoimmune conditionautoimmune disorderautoimmunity diseasebasebasescell biologyclustered regularly interspaced short palindromic repeats screeneffective therapyeffective treatmentgenome mutationgenome scalegenome-widegenomewideimmune receptorimprovedin vivoinsightknockin micemembermultidisciplinarynucleic acid deliverypathwaypsoriasiformpsoriaticreceptorresearch studyresponserheumatic arthritissocial roletrafficking
Description preview
PROJECT SUMMARY
Inappropriate recognition of self nucleic acids (NA) by members of the Toll-like receptor (TLR) family can
result in autoimmune diseases such as lupus and psoriasis. TLR7 (and TLR8 in humans) and TLR9 can be
activated by self RNA and DNA, respectively, so defining the mechanisms that limit responses by these TLRs
is highly…
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