grant
Regulation of T cell immunity
Organization VA SAN DIEGO HEALTHCARE SYSTEMLocation SAN DIEGO, UNITED STATESPosted 1 Apr 2025Deadline 31 Mar 2029
VANIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoVAML2AddressAdoptive TransferAirway mucosaAlgorithmic AnalysesAlgorithmic AnalysisAnalyses of AlgorithmsAnalysis of AlgorithmsAntibodiesAntigenic DeterminantsAreaBasal Transcription FactorBasal transcription factor genesBinding DeterminantsBioinformaticsBiologicalBiologyBiomedical ResearchBloodBlood Reticuloendothelial SystemBody SurfaceBody TissuesCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCITE sequencingCITE-seqCITEseqCOVID-19 virusCOVID19 virusCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCategoriesCause of DeathCell BodyCell DifferentiationCell Differentiation processCellsCellular Indexing of Transcriptomes and Epitopes by SequencingCellular biologyChemokine Receptor GeneCirculationClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCoV-2CoV2ColonCommunicable DiseasesComputer AnalysisDataDevelopmentDiseaseDisorderEconomic BurdenEdg ReceptorsEngineeringEpitopesExhibitsFKHRFOXO1FOXO1AFOXO1A geneForkhead Box O1AForkhead in RhabdomyosarcomaFoundationsGene TranscriptionGeneHomologGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGeneticGenetic TranscriptionGoalsGrippeHCV/HIVHIV and HCVHIV and hepatitis CHIV-HCVHIV/HCVHIV/Hepatitis CHealthHealth CareHomologHomologous GeneHomologueHumanImmuneImmune memoryImmune responseImmunesImmunityImmunologic MemoryImmunological MemoryInfectionInfectious DiseasesInfectious DisorderInfectious Skin DiseasesInflammationInfluenzaIntegrinsIntegrins Extracellular MatrixKidneyKidney Urinary SystemKnowledgeLCM VirusesLCMVLYT3LiverLymphatic TissueLymphocytic choriomeningitis virusLymphoid TissueMHC ReceptorMaintenanceMajor Histocompatibility Complex ReceptorMediatingMemoryMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMiceMice MammalsModelingModern ManMolecularMorbidityMorbidity - disease rateMucosaMucosal TissueMucous MembraneMurineMusNeoplasm MetastasisOrganPathogenesisPathway interactionsPersonal SatisfactionPlayPopulationPre-Clinical ModelPreclinical ModelsProteinsProteomicsPublic HealthRNA ExpressionRUNX3RUNX3 geneRegimenRepressionResearchResearch PriorityResidenciesRespiratory MucosaRoleRunt-Related Transcription Factor 3S1P ReceptorSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2Salivary GlandsSecondary NeoplasmSecondary TumorSentinelSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2SiteSkinSmall IntestinesSphingosine-1-Phosphate ReceptorSurfaceSystemT cell regulationT cell responseT memory cellT'ai ChiT-Cell Antigen ReceptorsT-Cell ReceptorT-CellsT-LymphocyteT8 CellsT8 LymphocytesTai ChiTai Chi ChihTai Chi ChuanTai JiTai Ji QuanTai QiTaiChiTaijiTaijiquanTamoxifenTestingTherapeuticTissue DifferentiationTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription RepressorTranscription factor genesTranscriptional RepressorTransgenic OrganismsTranslationsVaccinationVaccinesVeteransWuhan coronavirusadaptive immunityanamnestic reactionbiologiccancer metastasiscell biologycellular differentiationcellular indexing of transcriptomes and epitopes by single cell sequencingchemokine receptorcomputational analysescomputational analysiscomputer analysescoronavirus disease 2019 viruscoronavirus disease-19 viruscutaneous infectiondesigndesigningdevelopmentalepigenomicsfield based datafield learningfield studyfield testfirst respondergenetic repressorglobal gene expressionglobal transcription profilehCoV19hepatic body systemhepatic organ systemhost responseimmune system responseimmunoresponseimprovedindexinginfected skininnovateinnovationinnovativememory T lymphocytemicrobe pathogenmicrobial pathogenmilitary veteranmortalitynCoV2neutralizing antibodynew vaccinesnext generation vaccinesnovel vaccinespandemicpandemic diseasepathogenpathogenic microbepathwayprogramsrenalresponsesecondary immune responseskin infectionsmall bowelsocial rolethymus derived lymphocytetraffickingtranscription factortranscriptometranscriptomicstransgenictranslationtumor cell metastasistumor growthveteran populationwell-beingwellbeing
Description preview
Project Summary
Background and Innovation: Mortality from infectious diseases remains the second leading cause of death
worldwide, a fact highlighted by 4 years of a global pandemic, making the understanding of host responses,
development of new vaccines, and improving existing vaccines important priorities of biomedical research.
Memory T cells…
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