grant
Regulation of spatial organization and cell-cell communication in the islet of Langerhans
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 1 Jul 2019Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY202521+ years old3-D3-Dimensional3DAdultAdult HumanAdult-Onset Diabetes MellitusAffectAlpha CellAntidiabetic HormoneArchitectureAttentionB9 endocrine pancreasBeta CellBody TissuesCausalityCell BodyCell CommunicationCell Communication and SignalingCell DeathCell DifferentiationCell Differentiation processCell FunctionCell Growth in NumberCell InteractionCell LocomotionCell MaturationCell MigrationCell MovementCell MultiplicationCell PhysiologyCell ProcessCell ProliferationCell SignalingCell Surface ProteinsCell-Extracellular MatrixCell-to-Cell InteractionCellsCellular FunctionCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCellular ProliferationCessation of lifeCompensationD-GlucoseDataDeathDefectDevelopmentDextroseDiabetes MellitusDown-RegulationECMEmbryoEmbryonicEndocrineEndocrine PancreasEngineering / ArchitectureEpitheliumEtiologyEventExtracellular MatrixFailureFundingFutureGene TranscriptionGenesGenetic TranscriptionGestationGestational DiabetesGestational Diabetes MellitusGlucagonGlucagon CellGlucagon Secreting CellGlucoseGlukagonGoalsHG-FactorHormone secretionHumanHumulin RHyperglycemic-Glycogenolytic FactorImpairmentInsulinInsulin CellInsulin ResistanceInsulin Secreting CellIntracellular Communication and SignalingIslands of LangerhansIslet CellIslets of LangerhansKetosis-Resistant Diabetes MellitusKnock-outKnockoutLifeLigandsMaturity-Onset Diabetes MellitusMediatingMesenchymasMesenchymeMiceMice MammalsModelingModern ManMorphogenesisMurineMusNIDDMNesidioblastsNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RObesityPancreasPancreaticPancreatic IsletsParacrine CommunicationParacrine SignalingPars endocrina pancreatisPeripheralPersonsPositionPositioning AttributePregnancyPregnancy-Induced DiabetesPublishingRNA ExpressionReceptor ProteinRecoveryRegular InsulinRegulationRelaxationRodentRodentiaRodents MammalsRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusStable Diabetes MellitusStressStromal CellsSubcellular ProcessT2 DMT2DT2DMTestingTissuesTranscriptionType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesadiposityadult onset diabetesadulthoodalpha-cellbiological signal transductionblood glucose regulationcausationcell motilitycellular differentiationcorpulencedevelopmentaldiabetesdiabeticdiabetogenicdisease causationglobal gene expressionglobal transcription profileglucose controlglucose homeostasisglucose regulationhormonal regulationhormonal secretionhormone regulationin vivoinsulin resistantinsulin toleranceisletketosis resistant diabetesmaturity onset diabetesmorphogenetic processnecrocytosispostnatalpregnancy diabetespreventpreventingreceptorresponserestorationsocial rolethree dimensionaltranscriptometype 2 DMtype II DMtype two diabetesα-cellβ-cellβ-cellsβCell
Description preview
The most important determinant in whether a person will develop type 2 diabetes or gestational diabetes is
whether their islets of Langerhans are able to compensate for the increase demand for insulin brought about
by peripheral insulin resistance. In successful compensatory islet expansion (that can mitigate the develop-
ment of diabetes), islets…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click