grant
Regulation of Pulmonary Host Defenses by the Endoplasmic Reticulum Stress Sensor IRE1α
Organization LOUISIANA STATE UNIV A&M COL BATON ROUGELocation BATON ROUGE, UNITED STATESPosted 2 Jan 2019Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025(TNF)-α5,6,15-tri-HETE5,6,15-triHETE5,6,15-trihydroxy-7,9,11,13-eicosatetraenoic acidActive OxygenAcuteAddressAir PollutantsAlveolarAnatomic SitesAnatomic structuresAnatomyAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibioticsAsthmaAutoimmune DiseasesB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2Beta Proprotein Interleukin 1BiologyBlood NeutrophilBlood Polymorphonuclear NeutrophilBody TissuesBronchial AsthmaC-K-RASCachectinCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCellular StressCellular Stress ResponseChiro-InositolChronicChronic DiseaseChronic IllnessDataDevelopmentDinoprostoneDiseaseDisease OutcomeDisease ProgressionDisorderDrug Metabolic DetoxicationDrug Metabolic DetoxificationDrug resistanceER stressEconomic BurdenEnsureEnvironmental ToxinEnzyme GeneEnzymesExposure toFibrosing AlveolitisFosteringGasesGenerationsGeneticGoalsHPGFHealth Care FacilityHealth FacilitiesHepatocyte-Stimulating FactorHospital InfectionsHospital acquired infectionHost DefenseHumanHybridoma Growth FactorIFN-beta 2IFNB2IL-1 betaIL-1 βIL-1-bIL-1βIL-6IL1-BetaIL1-βIL1B ProteinIL1F2IL1βIL6 ProteinImmuneImmune infiltratesImmune mediated therapyImmune responseImmune signalingImmunesImmunologically Directed TherapyImmunomodulationImmunotherapyInfectionInflammation MediatorsInflammatoryInflammatory ResponseInhalationInhalingInositolInterleukin 1betaInterleukin-1 betaInterleukin-1βInterleukin-6Intracellular Communication and SignalingInvestigationK-RAS2AK-RAS2BK-RasK-Ras 2AK-Ras-2 OncogeneKRASKRAS2KRAS2 geneKi-RASKineticsLXA4LinkLipidsLungLung Alveolar EpitheliaLung DiseasesLung Respiratory SystemLung Tissue FibrosisLung infectionsMDR organismMDR pathogenMGI-2MRSAMacrophageMacrophage-Derived TNFMalignant CellMarrow NeutrophilMediatingMesoinositolMetabolic Drug DetoxicationsMetabolism of Toxic AgentsMethicillin Resistant S. AureusMiceMice MammalsMiscellaneous AntibioticMitochondriaModelingModern ManMonitorMonocyte-Derived TNFMorbidityMorbidity - disease rateMurineMusMyelogenousMyeloidMyeloid Differentiation-Inducing ProteinMφNational Institutes of HealthNeutrophilic GranulocyteNeutrophilic LeukocyteNosocomial InfectionsOncogene K-RasOrganOxygen RadicalsPGE2PGE2 alphaPGE2alphaPathogenesisPathologyPhagocytosisPlasmacytoma Growth FactorPneumoniaPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPositionPositioning AttributePreinterleukin 1 BetaPro-OxidantsProductionProstaglandin E2Prostaglandin E2 alphaProstaglandin E2alphaProtein DeficiencyPublishingPulmonary DiseasesPulmonary DisorderPulmonary FibrosisPulmonary PathologyRASK2Reactive Oxygen SpeciesRegulationResistance to antibioticsResistant to antibioticsResolutionRespiratory DiseaseRespiratory System DiseaseRespiratory System DisorderRoleS. aureus infectionSepsisSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteSkinStaph aureus infectionStaphylococcus aureus infectionStressSubcellular ProcessSystemTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTXNIPTXNIP geneTestingTherapeuticThioredoxin-Binding Protein 2Thioredoxin-Interacting ProteinTissuesToxic Environmental AgentsToxic Environmental SubstancesTransgenic MiceTumor Necrosis FactorTumor Necrosis Factor-alphaUnited StatesUnited States National Institutes of HealthVDUP1Vancomycin ResistanceVitamin D3-Upregulating Protein 1Workacute infectionalveolar epitheliumanti-microbialantibiotic drug resistanceantibiotic resistantantibiotic resistant pathogenantimicrobialautoimmune conditionautoimmune disorderautoimmunity diseasebacteria pathogenbacterial pathogenbactericidalbactericidebiological adaptation to stressbiological signal transductioncancer cellcare facilitiescatalasecell stresscellular targetingchronic disorderchronic inflammatory diseasecytokinedeficiency of proteindesigndesigningdetoxificationdevelopmentaldiffuse interstitial pulmonary fibrosisdisease controldisease of the lungdisorder controldisorder of the lungdrug resistantdrug resistant pathogenendoplasmic reticulum stressenvironmental toxicantepithelial to mesenchymal transitionexperimentexperimental researchexperimental studyexperimentsextracellularfibrosis in the lunghost responseidiopathic pulmonary fibrosisimmune cell infiltrateimmune modulating strategyimmune modulationimmune modulatory strategyimmune regulationimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunologic reactivity controlimmunomodulatoryimmunomodulatory strategyimmunoregulationimmunoregulatoryimmunoresponsein vivoinfected with S. aureusinfected with Staph aureusinfected with Staphylococcus aureusinflammatory mediatorinhibitorinnate immune functioninnovateinnovationinnovativeinsightinstitutional infectioninterferon beta 2interstitiallipoxin A4lung developmentlung disorderlung fibrosislung pathologymethicillin resistance Staphylococcus aureusmethicillin resistant Staphylococcus aureusmethicillin resistant strains of Staphylococcus aureusmicrobialmitochondrialmulti-drug resistant organismmulti-drug resistant pathogenmultidrug resistant organismmultidrug resistant pathogenmultiple drug resistant organismmultiple drug resistant pathogenneutrophilnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathogenpathogenic bacteriapharmacologicpulmonarypulmonary infectionsreaction; crisisresistance to Drugresistance to vancomycinresistant to Drugresistant to vancomycinresolutionsresponsesensorskin abscesssocial rolestress responsestress; reactionsubcutaneoussubdermalv-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homologvancomycin resistant
Description preview
SUMMARY
Methicillin-resistant Staphylococcus aureus (MRSA) is the leading cause of hospital-acquired infection
worldwide, causing approximately 14 million infections annually in the United States alone. Increasing antibiotic
resistance observed with this pathogen highlights a compelling need to identify new therapeutic targets to treat
MRSA…
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