grant
Regulation of PPM family serine/threonine phosphatases
Organization BRANDEIS UNIVERSITYLocation WALTHAM, UNITED STATESPosted 1 Jun 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2025AddressBacteriaBacterial PhysiologyCancersCell BodyCell Communication and SignalingCell Fate ControlCell Fate RegulationCell SignalingCellsComplexDephosphorylationDiseaseDisorderDrug TargetingFamilyGenesGoalsHereditaryHumanHuman GenomeInflammatoryInheritedIntracellular Communication and SignalingIsoformsKinasesKnowledgeL-SerineL-ThreonineLaboratoriesLifeMAP Kinase CascadesMAP Kinase ModulesMAP Kinase Signaling CascadesMAP kinaseMalignant NeoplasmsMalignant TumorMitogen-Activated Protein KinasesModern ManOutcome StudyPathway interactionsPhosphatasesPhosphohydrolasesPhosphomonoesterasesPhosphoprotein PhosphatasePhosphoprotein Phosphatase-2CPhosphoprotein PhosphohydrolasePhosphoric Monoester HydrolasesPhosphorylationPhosphorylation SitePhosphotransferase GenePhosphotransferasesProtein DephosphorylationProtein IsoformsProtein Phosphatase CProtein Phosphatase GeneProtein Phosphatase-1Protein Phosphatase-2AProtein PhosphorylationProtein phosphataseRegulationResearchSerineSignal PathwaySignal TransductionSignal Transduction SystemsSignalingThreonineTransphosphorylasesVirulenceWorkbiological adaptation to stressbiological signal transductionhuman whole genomemalignancyneoplasm/cancerpathwayreaction; crisissmall molecule therapeuticsstress responsestress; reactiontargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic target
Description preview
Project Summary/Abstract
Reversible protein phosphorylation controls essential cell fate decisions in all kingdoms of life.
Because of this, the kinases and phosphatases that control phosphorylation are often
dysregulated in disease and are attractive drug targets for therapeutics. The overarching goal of
work in the laboratory is to address two…
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