grant
Regulation of Plasmodium-specific CD4+ T cells
Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 26 Sept 2016Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2025AcuteAddressAgonistAmino Acid ChannelAmino Acid Transport SystemsAmino Acid TransporterAnti-malarialsAntibody ResponseAntigen-Presenting CellsApplied GeneticsB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBiologicalBiologyBloodBlood Reticuloendothelial SystemBlood erythrocyteCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCell BodyCell Communication and SignalingCell CompartmentationCell CompartmentationsCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCessation of lifeCommunicable DiseasesContracting OpportunitiesContractsDataDeathDepositDepositionDevelopmentDiseaseDisorderErythrocytesErythrocyticEventExpression SignatureFailureGene Expression ProfileGene TranscriptionGenetic TranscriptionGlnGlutamineGoalsGroups at riskHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHemoglobinHumoral ImmunitiesHypoxiaHypoxicImmuneImmune mediated therapyImmune responseImmunesImmunityImmunologically Directed TherapyImmunologyImmunomodulationImmunotherapyIndividualInducer CellsInducer T-LymphocytesInfectionInfectious DiseasesInfectious DisorderInflammasomeInflammationInnate ImmunityIntermediary MetabolismInterventionIntracellular Communication and SignalingJournalsKnowledgeL-GlutamineLinkMagazineMalariaMarrow erythrocyteMediatingMedicineMetabolicMetabolic ProcessesMetabolismMiceMice MammalsMolecularMolecular GeneticsMurineMusNative ImmunityNatural ImmunityNatureNon-Specific ImmunityNonspecific ImmunityOxygen DeficiencyPaludismParasite ControlParasitesParasitologyPathogenesisPathway interactionsPeople at riskPersons at riskPhysiologicPhysiologicalPlasmablastPlasmodiumPlasmodium InfectionsPopulationPopulations at RiskPredispositionPublicationsPublishingQ LevoglutamideQ. LevoglutamideRNA ExpressionReagentRed Blood CellsRed CellRegulationReportingResearchResistanceResolutionScientific PublicationSeverity of illnessSignal TransductionSignal Transduction SystemsSignalingSubcellular ProcessSusceptibilitySymptomsSystemT cell differentiationT cell responseT-Cell DevelopmentT-Cell OntogenyT-Cell SubsetsT-Lymphocyte DevelopmentT-Lymphocyte SubsetsT4 CellsT4 LymphocytesTestingTranscriptionVaccinesaccessory celladaptive immunityanti-malarial agentsanti-malarial drugsantibody-based immunitybeta-hematinbiologicbiological signal transductionblood corpusclesburden of diseaseburden of illnesscell mediated immune responsedevelopmentaldisease burdendisease severitydrinking waterfunctional improvementgene expression patterngene expression signaturegenetic approachgenetic strategyglobal health emergencyhaemozoinhemozoinhost responseimmune modulationimmune regulationimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimprove functionimproved functional outcomesinnovateinnovationinnovativemalaria pigmentnew approachesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel approachesnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapy targetpathogenpathwayprogramsresistantresolutionsresponsetranscriptional profiletranscriptional signaturetranscriptomics
Description preview
PROJECT SUMMARY
Plasmodium infections and the disease malaria remain global health emergencies. Plasmodium parasites
replicate within and cause the destruction of host red blood cells, which triggers inflammation and causes the
symptoms of malarial disease. Parasite-specific antibody responses that develop following infection are critical
for…
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