grant
Regulation of Osteoblasts by ACTH and VEGF
Organization VETERANS HEALTH ADMINISTRATIONLocation PITTSBURGH, UNITED STATESPosted 1 Oct 2014Deadline 30 Jun 2028
VANIHUS FederalResearch GrantFY20256-Methylprednisolone6Alpha-MethylprednisoloneACTHACTH ReceptorsAcetatesAdrenal Cortex HormonesAdrenal GlandsAdrenalsAdrenocorticotropic HormoneAdrenocorticotropic Hormone ReceptorsAdrenocorticotropinAnimal ModelAnimal Models and Related StudiesAutocrine SystemsBlood SerumBlood VesselsBlood capillariesBody TissuesBone GrowthBone necrosisCancellous boneCell BodyCell Communication and SignalingCell Culture TechniquesCell Growth in NumberCell MultiplicationCell ProliferationCell SignalingCellsCellular ProliferationCessation of lifeCircadian RhythmsClinicalComplexCorticoidsCorticosteroidsCorticotropinCorticotropin ReceptorsDeathDependenceDifferentiation and GrowthDomestic RabbitDoseEndocrine Gland SecretionEndothelial Growth Factors ReceptorFLT VEGF ReceptorFLT1 RTKFLT1 Receptor Tyrosine KinaseFeedbackFlt-1FrequenciesGlucocorticoidsHormonesHourHumanHypophysisHypophysis CerebriHypoxiaHypoxicImmuneImmunesIn VitroInflammatoryInjectionsIntracellular Communication and SignalingLymphatic cellLymphocyteLymphocyticMacrophageMeasuresMediatingMesenchymal Progenitor CellMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsMetabolicMethodsMethyl prednisoloneMethylprednisoloneMethylprednisolonumMetipredMiceMice MammalsModelingModern ManMurineMusMφNyctohemeral RhythmOryctolagus cuniculusOsteoblastsOsteonecrosisOxygen DeficiencyPathway interactionsPituitaryPituitary GlandPituitary Nervous SystemProductionProto-Oncogene Protein fltRabbitsRabbits MammalsReceptor Tyrosine Kinase,Class VRegulationRegulatory PathwaySerumSignal TransductionSignal Transduction SystemsSignalingSteroid CompoundSteroidsSystemT-CellsT-LymphocyteTherapeutic HormoneTimeTissuesTwenty-Four Hour RhythmTyrosine Protein Kinase FRTTyrosine Protein Kinase Receptor FLTVEGFVEGF Receptor flt-1 ProteinVEGFR-1VEGFR1VEGFsVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth FactorsWorkautocrinebiological signal transductionbonebone cellbone massbone turnovercapillarycell culturecell culturescircadian processcircadian rhythmicitycytokinedaily biorhythmfemur headfms-Like Tyrosine Kinasehuman diseasehuman modelin vivoinnovateinnovationinnovativelymph cellmesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsmodel of animalmodel of humannovelpathwaypreventpreventingresponsesubstantia spongiosasubstantia trabecularissuprarenal glandthymus derived lymphocytetissue culturetrabecular bonevascular
Description preview
We are studying how osteoblast death due to glucocorticoids (GCs) is counteracted by vascular
endothelial growth factor (VEGF). Developing osteoblasts express the ACTH receptor, and osteoblasts
express VEGF in response to the adrenocorticotropic hormone (ACTH). Continuous steroid treatment reduces
ACTH production to low levels. In rabbits with…
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