grant
Regulation of notochord vacuole biogenesis: investigating its role in spine formation and IVD Biology
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAffectAgingAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBeige ProteinBiogenesisBiologyBrachydanio rerioCHS proteinCHS1CHS1 ProteinCHS1 geneCausalityCell BodyCell FunctionCell PhysiologyCell ProcessCell-Extracellular MatrixCellsCellular FunctionCellular PhysiologyCellular ProcessChediak-Higashi Syndrome 1Chediak-Higashi Syndrome 1 GeneChickensChordataChordatesCongenital ScoliosisConserved SequenceCuesDanio rerioDedicationsDefectDevelopmentDiagnosisDiseaseDisorderDockingECMElementsEmbryoEmbryonicEtiologyExperimental ModelsExtracellular MatrixFamily suidaeGallus domesticusGallus gallusGallus gallus domesticusGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneticGenetic TranscriptionGenetic studyHumanImmune systemIntervertebral Disc Degenerative DiseaseIntervertebral Disc Degenerative DisorderIntervertebral DiskIntervertebral disc structureKinasesKnowledgeLYSTLineage TracingLinkLysosomal Trafficking RegulatorLysosomesMammaliaMammalsMediatingMembraneMembrane FusionMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMiceMice MammalsModern ManMorphogenesisMorphologyMurineMusNervous SystemNeurologic Body SystemNeurologic Organ SystemOrganOrganellesOrigin of LifeOrthopedic ProceduresOsteoblastsOutcomePathologyPatternPhosphorylationPhosphotransferase GenePhosphotransferasesPhysiologicPhysiologicalPigsPlayProtein PhosphorylationProteinsPublishingRNA ExpressionRegulationResearch SpecimenRodRoleSiteSpecific qualifier valueSpecifiedSpecimenSpinal ColumnSpineStressStructureSubcellular ProcessSuidaeSurface ProteinsSwineTestingThickThicknessTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTransphosphorylasesVacuoleVertebraeVertebralVertebral BodyVertebral columnVertebrate AnimalsVertebratesWorkZebra DanioZebra FishZebrafishadulthoodbackbonecausationcell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular lineage mappingcellular lineage trackingdegenerated intervertebral discdegenerative disc diseasedevelopmentaldisc degenerationdisease causationdrivinggenetic analysisinsightintervertebral disk degenerationmembrane biogenesismembrane structuremorphogenetic processnew approachesnotochordnovelnovel approachesnovel strategiesnovel strategynucleus pulposusporcineprogramspublic health relevancescaffoldscaffoldingsocial rolespine bone structuresuidtooltraffickingtranscription factortranscriptomicsvertebra bodyvertebrata
Description preview
ABSTRACT
The vertebral column or spine is the main structural element of the vertebrate body axis. It is assembled around
the notochord, a conserved axial structure that provides developmental cues for the development of other organs
and serves as a structural scaffold for the embryo in all chordates. Importantly, in vertebrates, the notochord…
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