grant
Regulation of Motile Cilia Assembly in Lung Disease
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 17 Aug 2015Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY202520S Catalytic Proteasome20S Core Proteasome20S Proteasome20S ProteosomeAddressAffectBinding SitesBiologicalBiologyCOPDCandidate Disease GeneCandidate GeneCausalityCell BodyCell Culture TechniquesCellsCellular StressCellular Stress ResponseChlamydomonasChronic Obstruction Pulmonary DiseaseChronic Obstructive Lung DiseaseChronic Obstructive Pulmonary DiseaseChronic lung diseaseCiliaCombining SiteCryo-electron MicroscopyCryoelectron MicroscopyCytoplasmDNA mutationDataDefectDevelopmentDiseaseDisorderDockingDysfunctionElectron CryomicroscopyEnvironmentEtiologyFailureFunctional disorderGene variantGenesGeneticGenetic ChangeGenetic DiversityGenetic VariationGenetic defectGenetic mutationGenotypeGoalsHumanImpairmentInjuryInterruptionKartagener SyndromeKartagener TriadKnowledgeLeadLungLung DiseasesLung Respiratory SystemLung infectionsMacropainMacroxyproteinaseMiceMice MammalsMicro-tubuleMicrotubulesModern ManMotilityMucous body substanceMucusMulticatalytic ProteinaseMurineMusMutationObstructive Lung DiseasesParticulatePathologicPathologyPathway interactionsPatientsPb elementPhenotypePhysiopathologyPolynesian bronchiectasisPrimary Ciliary DyskinesiasProcessProductionProsomeProteasomeProteasome Endopeptidase ComplexProteinsProteomicsProteosomePulmonary DiseasesPulmonary DisorderReactive SiteRegulationRespiratory infectious agentRespiratory tract pathogenRoleSecretory CellSeverity of illnessSkeletonStressStructureSyndromeTestingVariantVariationairway injuryallelic variantbiologiccausationcell culturecell culturescell stresscell typechronic obstructive pulmonary disorderchronic pulmonary diseasecilium motilityconnectomecryo-EMcryoEMcryogenic electron microscopydevelopmentaldisease causationdisease modeldisease of the lungdisease phenotypedisease severitydisorder modeldisorder of the lunggenetic variantgenome mutationgenomic variantheavy metal Pbheavy metal leadimpaired airwayinjured airwayinjurieslung disordermucousmulticatalytic endopeptidase complexobstructive pulmonary diseasesparticlepathogenpathophysiologypathwayprogramsprotein homeostasisproteostasisproteotoxicproteotoxicitypulmonary infectionsrespiratory injuryrespiratory pathogenrespiratory tract injuryscaffoldscaffoldingskeletonssocial role
Description preview
Project Summary/Abstract
Motile cilia are essential for airway clearance and their dysfunction leads to lung diseases. Loss of motile cilia
may be environmentally influenced in conditions like chronic obstructive lung disease, or due to genetic causes
that are collectively known as primary ciliary dyskinesia (PCD). The goal of our studies is to…
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