grant
Regulation of microglial function in Alzheimer's disease by sphingolipid metabolism and transport
Organization VA MEDICAL CENTER - LEXINGTON, KYLocation LEXINGTON, UNITED STATESPosted 1 Jan 2026Deadline 31 Dec 2030
VANIHUS FederalResearch GrantFY20264-SphingenineAD dementiaAD pathologyAD riskAD risk factorAD therapyAD treatmentAdoptedAffectAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer disease treatmentAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer treatmentAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's disease pathologyAlzheimer's disease riskAlzheimer's disease therapyAlzheimer's pathologyAlzheimer's therapyAlzheimers DementiaAmyloid (Aβ) plaquesAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid PlaquesAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAβBrainBrain InflammationBrain Nervous SystemBrain TraumaCell BodyCell Communication and SignalingCell NucleusCell SignalingCell membraneCell secretionCellsCellular SecretionCeramidesCytoplasmic MembraneDataDrugsEdg ReceptorsEncephalitisEncephalonEnzyme GeneEnzymesEquilibriumGene ExpressionGeneHomologGenerationsHD1HDAC AgentHDAC inhibitorHDAC1HDAC1 geneHistocompatibilityHistone Deacetylase 1Histone Deacetylase InhibitorHistone deacetylase inhibitionHomologHomologous GeneHomologueHortega cellHydrolysisImmuneImmunesInorganic Phosphate TransporterInositide PhospholipidsInositol PhosphoglyceridesInositol PhospholipidsIntermediary MetabolismIntracellular Communication and SignalingKnock-outKnockoutKnowledgeLeadMT-bound tauMedicationMemory DeficitMemory impairmentMetabolic ProcessesMetabolismMiceMice MammalsMicrogliaMolecularMurineMusNerve CellsNerve UnitNeural CellNeuritic PlaquesNeurocyteNeuronsNon-Polyadenylated RNANuclearNuclear TranslocationNucleusPIP2PTSDPathogenesisPathogenicity FactorsPathway interactionsPb elementPersonsPhagocytosisPhagocytosis InductionPharmaceutical PreparationsPhenotypePhosphate Transport ProteinsPhosphate TransportersPhosphatidyl InositolPhosphatidylinositol 4,5-BiphosphatePhosphatidylinositol 4,5-DiphosphatePhosphatidylinositol-4,5-BisphosphatePhosphatidylinositolsPhosphoinositidesPlasma MembranePost-Traumatic NeurosesPost-Traumatic Stress DisordersPosttraumatic NeurosesPrimary Senile Degenerative DementiaProcessProteinsPtIns 4,5-P2PtdInsPtdInsP2PublishingRNARNA Gene ProductsRNA SeqRNA sequencingRNAseqRPD3-Like 1RPD3L1Reduced Potassium Dependency 3, Yeast, Homolog-Like 1RegulationReporterResearchRibonucleic AcidRoleS1P ReceptorSenile PlaquesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSphingolipidsSphingomyelin CholinephosphohydrolaseSphingomyelin Cleaving EnzymeSphingomyelin PhosphodiesteraseSphingomyelinaseSphingomyelinase CSphingomyelinsSphingosineSphingosine-1-Phosphate ReceptorSubgroupSynapsesSynapticTau forming aggregatesTestingTissue CompatibilityTraumatic Brain InjuryVeteransVirulence Factorsa beta peptideabetaabnormally aggregated tau proteinaggregation in taualzheimer riskamyloid betaamyloid beta plaqueamyloid-b plaqueamyloid-b proteinantagonismantagonistaβ plaquesbalancebalance functionbeta amyloid fibrilbiological signal transductionbrain cellclinically approved drugclinically approved medicationclinically approved therapeutic agentcombatcored plaquecytokinediffuse plaquedrug/agentempowermentepigenetic regulationepigenomicsexposomeextracellularfilamentous tau inclusionfunctional plasticitygitter cellglial activationglial cell activationheavy metal Pbheavy metal leadhigh riskimprovedinsoluble aggregatelipidomicsmemory dysfunctionmesogliamicroglial cellmicrogliocytemicrotubule associated protein tau aggregationmicrotubule associated protein tau depositmicrotubule bound taumicrotubule-bound taumilitary servicemouse modelmurine modelneural inflammationneuroinflammationneuroinflammatoryneuronalneuroprotectionneuroprotectivenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypaired helical filament of taupathwayperivascular glial cellplasmalemmapost-trauma stress disorderposttrauma stress disorderpreventpreventingprimary degenerative dementiaprotein aggregateprotein aggregationresponserisk factor for developing Alzheimer'srisk factor in Alzheimer'srisk of developing Alzheimer'sself-aggregate tausenile dementia of the Alzheimer typesocial rolesoluble amyloid precursor proteinspatial memorysphingosine 1-phosphatesphingosine kinasesynapsetautau PHFtau Proteinstau accumulationtau aggregatetau aggregationtau factortau fibrillationtau fibrillizationtau filamenttau inclusiontau neurofibrillary tangletau oligomertau paired helical filamenttau polymerizationtau protein accumulationtau protein aggregationtau-tau interactiontranscriptome sequencingtranscriptomic sequencingtranscriptomicstraumatic brain damagetraumatic neurosisτ Proteinsτ aggregation
Description preview
Veterans are twice as likely to develop Alzheimer’s disease (AD) compared to persons without military service.
While it is well established that post-traumatic stress disorder (PTSD) or traumatic brain injury (TBI) significantly
contribute to the increased risk of developing AD in Veterans, it is not clear which molecular mechanism is
associated…
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