grant
Regulation of Hypervirulent Klebsiella pneumoniae Virulence by Environmental Signals in the Host
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 5 Feb 2026Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026AddressAdherenceAlimentary CanalAnabolismAnimalsAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibioticsAssayBacteriaBileBile JuiceBile fluidBioassayBiological AssayCapsulesCell Communication and SignalingCell SignalingCuesDataDevelopmentDigestive TractDiseaseDisorderDistalEnterocytesEnvironmentFutureGI TractGI colonizationGastrointestinal TractGastrointestinal tract structureGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenesGenetic TranscriptionGrantHumanInfectionIntestinalIntestinesIntracellular Communication and SignalingInvadedK pneumoniaeK. pneumoniaeKlebsiella pneumoniaeKnowledgeLifeMapsMediatingMicrobial BiofilmsMiscellaneous AntibioticModelingModern ManMolecularMulti-Drug ResistanceMultidrug ResistanceMultiple Drug ResistanceMultiple Drug ResistantPathogenesisPathogenicity FactorsPathway interactionsPhenotypePneumoniaProductionPublic HealthRNA ExpressionRNA SeqRNA sequencingRNAseqRegulationRegulonResearchResistanceResistance to Multi-drugResistance to MultidrugResistance to Multiple DrugResistance to antibioticsResistant to Multiple DrugResistant to antibioticsResistant to multi-drugResistant to multidrugRoleSepsisSignal TransductionSignal Transduction SystemsSignalingSystemic infectionTestingTherapeuticTranscriptionUrinary tract infectionUrinary tract infectious diseaseVirulenceVirulence Factorsalimentary tractantibiotic drug resistanceantibiotic resistantbile saltsbiofilmbiological signal transductionbiosynthesisbowelcapsuledevelopmentaldigestive canaldisease controldisorder controlexperimentexperimental researchexperimental studyexperimentsgastrointestinalgastrointestinal tract colonizationgenetic approachgenetic strategygut colonizationin vivointestinal colonizationmortalitymulti-drug resistantmultidrug resistantmutantnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetpathogenpathogenicity genepathwaypreventpreventingresistantresponsesocial roletraittranscriptome sequencingtranscriptomic sequencingurinary infectionvirulence genevirulent gene
Description preview
Project Summary/Abstract:
Hypervirulent Klebsiella pneumoniae (hvKp) poses an urgent public health threat
as a cause of severe infections, with growing concern due to emerging multidrug
resistance. While intestinal colonization precedes most hvKp infections, the regulatory
mechanisms controlling this crucial step remain poorly understood. Our…
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