grant
Regulation of Elevated Postexercise Insulin-stimulated Glucose Uptake by Skeletal Muscle
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 Jul 2024Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AAV vectorAAV-based vectorADP-Ribosylation Factor GTPase-Activating Protein with FG Repeats 1AGFG1AGFG1 geneARFGAP with FG Repeats 1AddressAdeno-Associated VirusesAdult-Onset Diabetes MellitusAmericanBiologicalBlood GlucoseBlood SugarCell Communication and SignalingCell SignalingCell surfaceCollaborationsCommon Rat StrainsCouplingDefectDependoparvovirusDependovirusEstrogen ReceptorsEventExerciseExocytosisFemaleGLUT 4 proteinGLUT4GLUT4 geneGLUT4 proteinGTPGlucose Binding ProteinGlucose Transport ProteinGlucose TransporterGoalsGuanosine TriphosphateHIV-1 REV-Binding ProteinHRB geneHRB proteinHealth BenefitHumanHumulin RHydrolysisInsulinInsulin ResistanceIntracellular Communication and SignalingIntracellular MembranesKetosis-Resistant Diabetes MellitusKnock-outKnockoutKnowledgeLeannessLinkMaturity-Onset Diabetes MellitusMeasuresMediatingMembraneMethodsMicroscopyModelingModern ManMolecularMuscleMuscle CellsMuscle ProteinsMuscle TissueMyocytesNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin ROutcomePhosphorylationPhysiologicPhysiologicalPrediabetesPrediabetes syndromePrediabetic StateProcessProtein AnalysisProtein PhosphorylationProteinsProtocolProtocols documentationPublic HealthRAB geneRAB proteinREV-Interacting ProteinREV/REX Activation Domain-Binding ProteinRIP geneRIP proteinRatRats MammalsRattusRecommendationRegular InsulinRegulationReportingResearchResolutionRestRoleSamplingSignal TransductionSignal Transduction SystemsSignalingSiteSkeletal MuscleSlow-Onset Diabetes MellitusSortingStable Diabetes MellitusT2 DMT2DT2DMTestingTextThinnessType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesVesicleVoluntary Muscleadeno associated virus groupadeno-associated viral vectoradeno-associated virus vectoradult onset diabetesbiologicbiological signal transductiondesigndesigningglucose disposalglucose uptakehigh riskimprovedinsulin regulationinsulin resistantinsulin stimulated glucose disposalinsulin toleranceinsulin-responsive glucose transporterketosis resistant diabetesmalematurity onset diabetesmembrane structuremuscularnew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapypre-diabetespre-diabeticprediabeticpreventpreventingprotein expressionrecruitresolutionssedentarysexsex dimorphismsexual dimorphismsexually dimorphicsocial roletype 2 DMtype II DMtype two diabetes♀♂
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Over 130 million Americans suffer from the devastating consequences of type 2 diabetes (T2D) or prediabetes. Skeletal muscle accounts for up to 85% of insulin-induced blood glucose clearance, and insulin resistance…
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