grant
Regulation of disease progression by ER stress
Organization UNIVERSITY OF ALABAMA AT BIRMINGHAMLocation BIRMINGHAM, UNITED STATESPosted 20 Aug 2025Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025ATF-3ATF3AdipocytesAdipose CellAntimorphic mutationApoptosisApoptosis PathwayAsbestosAsbestosisBindingBlood monocyteCancersCardiac Failure CongestiveCell BodyCell NucleusCellsCessation of lifeChIP SequencingChIP-seqChIPseqChronic lung diseaseCongestive Heart FailureCoupledDNA mutationDataDeathDiseaseDisease ProgressionDisorderDominant NegativeDominant-Negative MutantDominant-Negative MutationER stressExposure toFat CellsFibroblastsFibrosisGenesGenetic ChangeGenetic defectGenetic mutationHeart DecompensationLipocytesLiver FibrosisLungLung Respiratory SystemLung Tissue FibrosisMacrophageMacrophage ActivationMalignant NeoplasmsMalignant TumorMarrow monocyteMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMature LipocyteMature fat cellMediatingMessenger RNAMetabolicMiceMice MammalsMolecularMolecular InteractionMurineMusMutationMφNucleusObesityOxidative PhosphorylationOxidative Phosphorylation PathwayPathogenesisPhenotypePhosphatasesPhosphohydrolasesPhosphomonoesterasesPhosphoric Monoester HydrolasesPlayProgrammed Cell DeathPulmonary FibrosisRegulationResistanceResolutionRoleSiteTestingToxic effectToxicitiesUnited StatesWorkactivating transcription factor 3adipositybiological adaptation to stresscell typechromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingchronic heart failurechronic pulmonary diseasecorpulencecurative interventioncurative therapeuticcurative therapycurative treatmentsendoplasmic reticulum stressexposed human populationfatty acid oxidationfibrosis in the lungfibrotic livergenome mutationhepatic fibrosishuman exposurein vivoinhibitorinsightlung fibrosismRNAmalignancymetabolic profilemonocyteneoplasm/canceroverexpressoverexpressionpromoterpromotorreaction; crisisrecruitresistantresolutionsresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestress responsestress; reactiontherapeutic target
Description preview
There is no current curative therapy for asbestos-induced fibrosis. Recruited monocyte-derived
macrophages (MDMs)play a critical role in the pathogenesis of asbestos-induced disease progression.
The activation of MDMs is dependent on their metabolic profile. Metabolic reprogramming is a key feature
in macrophage activation; however, the regulation…
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