grant
Regulation of ceramide-1-phosphate metabolism in cell signaling networks
Organization UNIVERSITY OF VIRGINIALocation CHARLOTTESVILLE, UNITED STATESPosted 15 Sept 2025Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AblationActive OxygenAgonistAnabolismBinding SitesBiochemical PathwayBiogenesisBiologic ModelsBiological ModelsCancersCardiacCardiolipinsCell BodyCell Communication and SignalingCell DeathCell FunctionCell PhysiologyCell ProcessCell ProtectionCell SignalingCell modelCellsCellular FunctionCellular PhysiologyCellular ProcessCellular StressCellular Stress ResponseCellular biologyCellular modelCeramidesCombining SiteCytoprotectionDataDegenerative Neurologic DisordersDephosphorylationDiseaseDisorderDysfunctionEsterificationFunctional disorderGenetics-MutagenesisGlycolysis InductionHexose Monophosphate ShuntImmuneImmunesInflammatoryIntermediary MetabolismIntracellular Communication and SignalingIntracellular Second MessengerLab FindingsLaboratory FindingLinkLipidsLipopolysaccharidesMacrophageMalignant NeoplasmsMalignant TumorMembrane PotentialsMetabolicMetabolic NetworksMetabolic ProcessesMetabolismMitochondriaMitochondrial PorinModel SystemModelingMolecularMutagenesisMutagenesis Molecular BiologyMφNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsOrigin of LifeOuter Mitochondrial MembraneOxidative PhosphorylationOxidative Phosphorylation PathwayOxygen RadicalsPLA2G4APLA2G4A genePathway interactionsPentose Phosphate PathwayPentose Phosphate ShuntPentose ShuntPentosephosphate PathwayPentosephosphate ShuntPhospholipase A2 Group IVAPhospholipase A2, Cytosolic, Calcium-Dependent, AlphaPhosphorylationPhysiopathologyPolyunsaturated Fatty AcidsPro-OxidantsProliferatingProtein DephosphorylationProtein PhosphorylationReactive Oxygen SpeciesReactive SiteRegulationResting PotentialsRoleSecond Messenger SystemsSecond MessengersSepsisSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSphingolipidsSubcellular ProcessTherapeuticTranslatingTransmembrane PotentialsTubulinTubulin InteractionUpregulationVDAC mitochondrial porinVDAC proteinsVoltage-Dependent Anion ChannelWound Repairaerobic glycolysisanion-selective channels voltage-dependentbiological signal transductionbiophysical approachesbiophysical methodologybiophysical methodsbiophysical techniquesbiosynthesiscPLA2-Alphacell biologycell stressceramide 1-phosphateceramide kinasecytoprotectivedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesfat metabolismin vivoinduced Creinducible Creinnovateinnovationinnovativelipid metabolismmalignancymitochondria porinsmitochondrialmitochondrial membranemitochondrial pore proteinmouse modelmurine modelmutantnecrocytosisneoplasm/cancerneurodegenerative illnessnovelpathophysiologypathwaypore forming protein VDACrecruitresponsesensorsignal transduction second messengerssocial roletoolvoltage-dependent, anion-selective, channel forming protein, mitochondrialwound healingwound recoverywound resolution
Description preview
Metabolic reprogramming (MR) is an important cellular mechanism in response to cell stress & agonist-induced proliferation/polarization, which is characterized by the suppression of oxidative phosphorylation (OXPHOS) & subsequent upregulation of aerobic glycolysis, lipid metabolism, mitochondrial fission, and the oxidative pentose phosphate…
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