grant
Regulation of cardiac pacemaker cell cytoarchitecture
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 5 Apr 2019Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY202521+ years oldAccessory SinusesAdultAdult HumanAgingArtificial PacemakerArtificial cardiac pacemakerAutoregulationBehaviorBindingBiologic ModelsBiologicalBiological ModelsBiomechanicsBiosensorBody TissuesCardiacCardiac developmentCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCell-Extracellular MatrixCellsCellular FunctionCellular PhysiologyCellular ProcessCharacteristicsClinicalCollectionCyclicityDataDevelopmentDevicesDiseaseDisease ProgressionDisorderDropsDysfunctionECMEncapsulatedEnvironmentExtracellular MatrixFeedbackFunctional disorderFundingGene TranscriptionGenerationsGenesGenetic TranscriptionHeartHeart failureHomeostasisHumanIntracellular Communication and SignalingLifeLigandsLinkMeasuresMechanicsMediatingModel SystemModelingModern ManMolecularMolecular InteractionMorphogenesisMyocardialMyocardial ContractionNasal SinusesNasal cavity/ParanasalNasal cavity/Paranasal sinusesNerve CellsNerve UnitNeural CellNeurocyteNeuronsNodalOperative ProceduresOperative Surgical ProceduresParacrine CommunicationParacrine SignalingParanasal SinusesPathologicPathway interactionsPatientsPatternPeriodicityPhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPrevalenceProcessProductionPropertyRNA ExpressionRegulationRepressionRestRhythmicityS-A NodeSA node dysfunctionSick Sinus SyndromeSignal TransductionSignal Transduction SystemsSignalingSino-Atrial NodeSinoatrial NodeSinu-Atrial NodeSinuatrial NodeSinusStructureSubcellular ProcessSudden DeathSupporting CellSurgicalSurgical InterventionsSurgical ProcedureSyndromeSystemTestingTherapeuticTissue EngineeringTissuesTranscriptionWorkadulthoodbioengineered tissuebiologicbiological sensorbiological signal transductionbiomechanicalcardiac agingcardiac failurecardiac pacemaker cellcardiogenesiscell typecellular pathologycohortdesigndesigningdevelopmentalengineered tissuegain of functionheart agingheart contractionheart developmentheart formationhemodynamicshuman modelimplantationin vivoinsightinterstitialinterstitial cellmechanicmechanicalmodel of humanmorphogenetic processneuronalnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnodal myocytenovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypacemaker cellparacrinepathophysiologypathwaypreservationprogramsresponserhosegregationsinoatrial node dysfunctionsinus nodesinus node dysfunctionsurgerytreatment strategyviscoelasticity
Description preview
ABSTRACT:
Cardiac pacemaker cells (CPCs) rhythmically initiate the electrical impulses that stimulate heart contraction. CPC
dysfunction co-segregates with a broad variety of both cardiac and non-cardiac disease conditions and represents the
leading cause for the surgical implantation of artificial pacemakers. Moreover, CPC dysfunction is a…
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