grant
Regulation of B cell Responses in SLE and Other Autoimmune Diseases
NIHUS FederalResearch GrantFY2025AddressAlpha-Beta-Omega Interferon Receptor-1Antiviral Protein Alpha TypeAssayAutoantibodiesAutoimmuneAutoimmune DiseasesAutoimmune StatusAutoimmunityB blood cellsB cellB cell depletion therapyB cell directed therapyB cell targeted therapyB cell therapiesB cell therapyB cellsB-Cell SubsetsB-CellsB-Lymphocyte SubsetsB-LymphocytesB-cellBar CodesBasal Transcription FactorBasal transcription factor genesBenlystaBioassayBiological AgentBiological AssayBiological ProductsCAR T cell therapyCAR T therapyCaringCell BodyCell Communication and SignalingCell CompartmentationCell CompartmentationsCell CountCell Fate ControlCell Fate RegulationCell IsolationCell MaturationCell NumberCell SegregationCell SeparationCell Separation TechnologyCell SignalingCell SurvivalCell ViabilityCell surfaceCellsCellular biologyChromatinChromatin StructureChromosome MappingClinicComprehensionCoupledDNADNA MethylationDeoxyribonucleic AcidDiseaseDisease remissionDisorderEnvironmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFc ReceptorFutureGene LocalizationGene MappingGene Mapping GeneticsGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGeneticGenetic TranscriptionHealthHereditaryHeterogeneityHuIFN-Alpha-RecHumanIFNIFNBRIFRCImmune mediated therapyImmunologically Directed TherapyImmunotherapyIndividualInheritedInterferon Alpha-Beta Receptor Alpha ChainInterferon ReceptorInterferon Type IInterferonsIntracellular Communication and SignalingLinkage MappingLupus Erythematosus DisseminatusMapsMediatorMemoryMemory B CellMemory B-LymphocyteModern ManMolecularMolecular FingerprintingMolecular ProfilingNon-Polyadenylated RNAPathway interactionsPatientsPhenotypePlayPopulationPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPredispositionProcessProtein ModificationRNARNA ExpressionRNA Gene ProductsRegulationRemissionRepressionRestRibonucleic AcidRoleSLESeriesSeverity of illnessSignal TransductionSignal Transduction SystemsSignalingSingle cell seqSpecific qualifier valueSpecifiedStaining methodStainsSurfaceSusceptibilitySystemic Lupus ErythematosusSystemic Lupus ErythematousSystemic Lupus ErythmatosusTechnologyTestingTotal Human and Non-Human Gene MappingTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTreatment EfficacyTreatment ProtocolsTreatment RegimenTreatment ScheduleWorkanalysis pipelineantibody receptorautoimmune antibodyautoimmune conditionautoimmune disorderautoimmunity diseaseautoreactive antibodybarcodebasebasesbelimumabbio-informatics pipelinebioinformatics pipelinebiological signal transductionbiologicsbiopharmaceuticalbiotherapeutic agentcell biologycell sortingcell typechimeric antigen receptor (CAR) T cell therapychimeric antigen receptor T cell therapychimeric antigen receptor T therapydisease severitydisseminated lupus erythematosusepigeneticallyepigenomeepigenomicsgenetic mappingglobal gene expressionglobal transcription profilehistone modificationifnar1 gene productimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimprintinhibitorinterestintervention efficacymolecular biomarkermolecular markermolecular profilemolecular signaturenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathwaypatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypesprogramsresponseself reactive antibodysingle cell next generation sequencingsingle cell sequencingsocial rolesuccesssystemic lupus erythematosistherapeutic efficacytherapy efficacytooltraittranscription factortranscriptometranscriptomicstype I IFN receptortype I interferon receptor
Description preview
Autoimmune disease represents a significant health problem. Over the decade, novel immune based therapies
to treat autoimmune diseases, such as those used in systemic lupus erythematosus (SLE) have met
considerable efficacy challenges. This suggests that there is considerable heterogeneity in the disease, which
could occur at the genetic level,…
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