grant
Regulation of autophagy during animal development
Organization UNIV OF MASSACHUSETTS MED SCH WORCESTERLocation WORCESTER, UNITED STATESPosted 1 Apr 2019Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY2025AnimalsAutophagocytosisBiologicalCancersCell BodyCell DeathCellsCytoplasmDefectDevelopmentDiseaseDisorderDrosophilaDrosophila genusEndoplasmic ReticulumEndosomesEnterocytesErgastoplasmGenesGeneticGenomicsHealthHumanInflammatoryIntestinalIntestinesKnowledgeLysosomesMalignant NeoplasmsMalignant TumorMammaliaMammalsMidgutMitochondriaModelingModern ManNerve DegenerationNeuron DegenerationOrganellesPathway interactionsPhysiologicPhysiologicalPlayProcessReceptosomesRegulationResearchResolutionRoleSystemTherapeuticYeastsautophagybiologicbowelcell typedesigndesigningdevelopmentalfruit flyhuman diseaseinsightinterestmalignancymitochondrialmitochondrial autophagynecrocytosisneoplasm/cancerneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationnovelpathwayprogramsrecruitresolutionssocial roletool
Description preview
PROJECT SUMMARY
Autophagy is used by all cells to deliver cytoplasmic material to the lysosome for degradation.
Significantly, autophagy has been implicated in several human diseases, including inflammatory
disorders, cancer and neurodegeneration. Most of what we know about the regulation of
autophagy is based on pioneering studies in yeast that…
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