grant
Regulation of Argonaute Nuclear Import in Mediating Transgenerational Fertility
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 4 Aug 2025Deadline 3 Aug 2029
NIHUS FederalResearch GrantFY2025AddressAffectAssayBindingBinding ProteinsBioassayBiologicalBiological AssayBiological FunctionBiological ProcessC elegansC. elegansC.elegansCRISPRCRISPR/Cas systemCaenorhabditis elegansCancersCell NucleusClustered Regularly Interspaced Short Palindromic RepeatsCo-ImmunoprecipitationsComplexCytoplasmic GranulesDNA Molecular BiologyDNA mutationDataDefectDevelopmentDiseaseDisorderEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEnsureFecundabilityFecundityFertilityGametogenesisGene InactivationGene SilencingGene Silencing PathwayGenesGenetic ChangeGenetic ScreeningGenetic defectGenetic mutationGenital DisordersGenome StabilityGenomic StabilityGermGerm LinesGoalsHealthHeterochromatinHumanImportinsLigand Binding ProteinLigand Binding Protein GeneMalignant NeoplasmsMalignant TumorMediatingMethylationModern ManMolecularMolecular BiologyMolecular InteractionMutateMutationN-terminalNH2-terminalNeurodevelopmental DisorderNeurological Development DisorderNuclearNuclear ImportNuclear RNANucleusOrganismOutcomePathway interactionsPhenotypePhosphorylationPost-Transcriptional Gene SilencingPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational Modification SitePost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational Modification SitePosttranslational ModificationsPosttranslational Protein ProcessingPregnancy lossProcessProtein BindingProtein ModificationProtein PhosphorylationProteinsRNA BindingRNA InterferenceRNA Interference PathwayRNA SilencingRNA boundRNAiRecurrenceRecurrentRegulationRegulatory PathwayReproductive System DiseaseResearchRoleSequence-Specific Posttranscriptional Gene SilencingSiteSmall RNASpecificitySyndromeSystemTestingTherapeuticTranscriptbiologicbound proteindevelopmentaldevelopmental diseasedevelopmental disorderexperimentexperimental researchexperimental studyexperimentsfluorescence imagingfluorescent imaginggene conservationgenome integritygenome mutationgenomic integritygranuleinnovateinnovationinnovativeinsightknock-downknockdownliving systemmalignancymutantneoplasm/cancerneurodevelopmental diseasepathwayprotein structureprotein structuresproteins structurerecruitreproductive diseasereproductive disorderreproductive system disorderscreeningscreeningssocial roletranscriptional silencingtransgenerational epigenetic inheritancetransgenerational inheritance
Description preview
PROJECT SUMMARY
Nuclear RNA interference (RNAi) is a conserved gene regulatory pathway that is essential for transgenerational
fertility and genome stability. Mediated by Argonaute proteins and small RNAs, nuclear RNAi ensures proper
regulation of vital processes such as accurate gametogenesis, proper embryonic development, and transposon…
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