grant
Regulation of amidase activity during spore development
Organization TUFTS UNIVERSITY BOSTONLocation BOSTON, UNITED STATESPosted 30 Apr 2026Deadline 29 Apr 2029
NIHUS FederalResearch GrantFY2026Active SitesAcuteAddressAffectApo-CApoCApolipoproteins CAssayAutomobile DrivingB subtilisB. subtilisBacillus subtilisBacteriaBindingBioassayBiochemicalBioinformaticsBiological AssayC diffC difficileC perfringensC welchiiC. diffC. difficileC. perfringensC. welchiiCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessChromosome MappingClostridioides difficileClostridium difficileClostridium perfringensClostridium welchiiCo-ImmunoprecipitationsCommunicationComplementComplement ProteinsComplexCytologyDataDeacetylaseDefectDevelopmentDiseaseDisorderEnzyme GeneEnzymesExhibitsFamilyFluorescence Light MicroscopyFluorescence MicroscopyFutureGene DeletionGene LocalizationGene MappingGene Mapping GeneticsGeneticGenetics-MutagenesisGerminationGoalsIn VitroInfectionLactamsLifeLinkage MappingLipoproteinsLytA enzymeLytic enzymeMediatingMembraneMetabolicModelingModificationMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMorphologyMureinMutagenesisMutagenesis Molecular BiologyOrganismOrthologOrthologous GenePatternPeptidoglycanPlayProcessRegulationReproduction sporesRoleShapesSiteSporesStructureSubcellular ProcessTM DomainTestingThickThicknessTotal Human and Non-Human Gene MappingTransmembrane DomainTransmembrane RegionVirulenceWorkacylamidaseacylaseamidasecofactorcommunicable disease transmissioncomparativecomplementationconformationconformationalconformational stateconformationallyconformationsdevelopmentaldisease transmissiondrivinggene deletion mutationgenetic mappingin silicoinfectious disease transmissioninsightliving systemmajor amidasemembrane structuremutantnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathogenpreventpreventingprotein protein interactionsocial roletherapeutic agent developmenttherapeutic development
Description preview
PROJECT SUMMARY/ABSTRACT
Spore germination is essential for clostridial pathogens to initiate disease. During germination, spores degrade
their protective cortex, a thick layer of modified peptidoglycan (PG) that maintains metabolic dormancy. The
cortex lytic enzymes that specifically degrade the cortex recognize the cortex-specific PG…
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