grant
Regulation and tumorigenesis of non-classical RAS oncoproteins - Resubmission
Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 1 Jan 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2025Adaptor ProteinAdaptor Protein GeneAdaptor Signaling ProteinAdaptor Signaling Protein GeneAllelesAllelomorphsAssayBindingBinding ProteinsBioassayBiochemicalBiological AssayBiological FunctionBiological MarkersBiological ProcessBladder CancerCancer BiologyCancer ModelCancer cell lineCancerModelCancersCell BodyCell Communication and SignalingCell Growth in NumberCell MultiplicationCell ProliferationCell SignalingCellsCellular ExpansionCellular GrowthCellular ProliferationChemicalsClinicClinicalComplexCuesCullin Homolog 3DNA mutationDevelopmentDimerizationDiseaseDisorderDrug TherapyE3 LigaseE3 Ubiquitin LigaseExpression SignatureFamilyFutureGTP PhosphohydrolasesGTPasesGene Expression ProfileGeneralized GrowthGenesGenetic ChangeGenetic defectGenetic mutationGlioblastomaGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaGrowthGuanosine 5'-DiphosphateGuanosine DiphosphateGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesHydrolaseHydrolase Family GeneHydrolase GeneHydrolysisImpairmentIn VitroIntracellular Communication and SignalingKnowledgeLigand Binding ProteinLigand Binding Protein GeneLung AdenocarcinomaMEKsMacromolecular Protein ComplexesMalignant Bladder NeoplasmMalignant MelanomaMalignant NeoplasmsMalignant TumorMalignant Tumor of the BladderMalignant Tumor of the LungMalignant neoplasm of lungMalignant neoplasm of urinary bladderMediatingMedicineMelanomaMetabolic Protein DegradationModelingMolecularMolecular ConfigurationMolecular ConformationMolecular FingerprintingMolecular InteractionMolecular ProfilingMolecular StereochemistryMouse StrainsMultiprotein ComplexesMutationNatureNucleotidesOncogene ProductsOncogene ProteinsOncogenesisOncogenicOncoproteinsPathway interactionsPeptide DomainPharmacological TreatmentPharmacotherapyPhysiologicPhysiologicalPlayPre-Clinical ModelPreclinical ModelsProcessProliferatingProtacProtein BindingProtein CleavageProtein DimerizationProtein DomainsProtein TurnoverProteinsProteolysisProteolysis targeting chimericProtomerPulmonary CancerPulmonary malignant NeoplasmRegulationRegulatory Protein DegradationReproducibilityResistanceRoleSeriesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSomatic MutationSpecificityStructureStructure-Activity RelationshipSubstrate SpecificityTechnologyTertiary Protein StructureTherapeuticTissue GrowthTumor SubtypeUbiquitilationUbiquitin Ligase Component GeneUbiquitin Ligase GeneUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3UbiquitinationUbiquitinoylationUrinary Bladder CancerUrinary Bladder Malignant TumorWorkadapter proteinbio-markersbiologic markerbiological signal transductionbiomarkerbound proteincancer initiationcancer sub-typescancer subtypescancer typecell growthchemical structure functioncofactorconformationconformationalconformational stateconformationallyconformationscullin-3develop therapydevelopmentaldrug interventiondrug treatmentexperimentexperimental researchexperimental studyexperimentsgene expression patterngene expression signaturegenetic approachgenetic strategygenome mutationglioblastoma multiformeguanosinetriphosphatasein vivoinhibitorinnovateinnovationinnovativeinsightintervention developmentleukemialoss of function mutationlung cancermalignancymembermolecular profilemolecular signaturemouse geneticsmouse modelmurine modelneoplasm/cancernew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachontogenypathwaypharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsprotein degradationproteolysis targeting chimaeraproteolysis targeting chimeraras Gene Productsras Proteinsresistance to therapyresistantresistant to therapyresponsesmall moleculesocial rolesomatic variantspongioblastoma multiformestructure function relationshiptargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic resistancetherapeutically effectivetherapy developmenttherapy resistanttranscriptional profiletranscriptional signaturetreatment developmenttreatment resistancetumortumor growthtumorigenesisubiquinationubiquitin conjugationubiquitin ligaseubiquitin-protein ligase
Description preview
PROJECT SUMMARY
Oncoproteins drive tumor development and aggressive growth by dysregulating the signaling pathways involved
in cell growth, survival, and proliferation. Targeting oncoproteins directly, or their downstream pathways, has
resulted in novel therapies currently being used for the treatment of different cancer subtypes.
The RAS family…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click