grant
Regulation and function of DNMT3A-mediated methylation in the brain.
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 26 Aug 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY202521+ years oldASDAddressAdultAdult HumanAffectAlanineAmino AcidsAnimal BehaviorAutismAutistic DisorderBehaviorBehavior assessmentBehavioralBindingBrainBrain Nervous SystemCNS Nervous SystemCentral Nervous SystemCerebroatrophic HyperammonemiaCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalDNADNA MethyltransferaseDNA Modification MethylasesDNA Modification MethyltransferasesDNA mutationDNA-Binding ProteinsDNA-MethyltransferasesDNMT3aDataDefectDeoxyribonucleic AcidDepositDepositionDiseaseDisorderDisturbance in cognitionDnmtEC 2.1.1Early Infantile AutismEncephalonEnzyme GeneEnzymesExhibitsGene Action RegulationGene Down-RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenesGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomeHumanImpaired cognitionIn VitroIndividualInfantile AutismIntellectual disabilityIntellectual functioning disabilityIntellectual limitationKanner's SyndromeL-SerineLeadLifeMeCP-2 proteinMeCP2MeCP2 proteinMediatingMethyl CpG binding protein MeCP2Methyl-CpG-Binding Protein 2Methyl-DNA binding protein MECP2MethylationMethyltransferaseMiceMice MammalsModelingModern ManModification MethylasesMolecularMolecular InteractionMurineMusMutant Strains MiceMutateMutationNeonatalNerve CellsNerve UnitNervous SystemNervous System DiseasesNervous System DisorderNeural CellNeuraxisNeurocyteNeurologicNeurologic Body SystemNeurologic DisordersNeurologic ManifestationsNeurologic Organ SystemNeurologic Signs and SymptomsNeurologic SymptomsNeurologicalNeurological DisordersNeurological ManifestationsNeurological Signs and SymptomsNeuronsOutcomePatternPb elementPhosphorylationPhosphorylation SiteProtein PhosphorylationProteinsRNA ExpressionRegulationRepressionRett DisorderRett SyndromeRoleSensorySerineShapesSiteSite-Specific DNA-methyltransferaseTestingTranscriptionTranscription Repressionadulthoodaminoacidautism spectral disorderautism spectrum disorderautistic spectrum disorderbehavioral assessmentbrain healthcell typecognitive dysfunctioncognitive lossdefined contributionexperienceexperimentexperimental researchexperimental studyexperimentsfascinategene manipulationgene repressiongenetic manipulationgenetically manipulategenetically perturbgenome mutationhDNA methyltransferase 3aheavy metal Pbheavy metal leadin vivoinsightintellectual and developmental disabilitylimited intellectual functioningmethylasemouse mutantneuralneural manifestationneurological diseaseneuronalneuronal circuitneuronal circuitryneuropsychiatric diseaseneuropsychiatric disordernew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpostnatalrecruitsocial roletherapeutic agent developmenttherapeutic developmenttransmethylase
Description preview
Project Summary:
The DNA methyltransferase DNMT3A is mutated in individuals with neurological disorders such as autism and
intellectual disabilities. DNMT3A is highly expressed in the nervous system, primarily methylating atypical non-
CG sequences, particularly at CA sites (mCA). The mCA mark is partially bound by MECP2, a protein mutated
in Rett…
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