grant
Regulating Inosine 5'-Monophosphate Dehydrogenase in Healthy and Diseased Photoreceptor Cells
Organization UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTRLocation OKLAHOMA CITY, UNITED STATESPosted 1 May 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY20265'-Inosinic acidATP-protein phosphotransferaseAddressAffectAffinityAutoregulationBindingBiochemicalBiologyBlindnessCOBRECatalysisCell BodyCell Communication and SignalingCell IsolationCell SegregationCell SeparationCell Separation TechnologyCell SignalingCell SurvivalCell ViabilityCellsCenter of Biomedical Research ExcellenceCenters of Research ExcellenceCiliaDNA mutationDataDehydrogenasesDiseaseDisorderEnvironmentEnzyme GeneEnzyme KineticsEnzymesEquilibriumExposure toExtracellular Signal-Regulated Kinase GeneFamilyFeedbackGTPGenesGenetic ChangeGenetic defectGenetic mutationGuanineGuanine NucleotidesGuanosine PhosphatesGuanosine TriphosphateHereditaryHomeostasisHumanIMP DehydrogenaseIncidenceIncubatedInheritedInosine MonophosphateInosine-5-Monophosphate DehydrogenaseInosinic Acid DehydrogenaseIntracellular Communication and SignalingInvestigationKO miceKinase Family GeneKinasesKineticsKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeLengthLightLight Signal TransductionLinkMAP Kinase GeneMAPKMitogen-Activated Protein Kinase GeneModelingModern ManMolecularMolecular InteractionMutationNucleotide BiosynthesisNucleotidesNull MouseOklahomaOrganoidsOutcomeOxidoreductaseOxidoreductase GenePathway interactionsPatientsPhenotypePhosphotransferase GenePhosphotransferasesPhotoradiationPhotoreceptor CellPhotoreceptorsPhotosensitive CellPhototransductionPhysiological HomeostasisPigmentary RetinopathyPlayProtein KinaseProteinsPurinesRalDH1ReductasesRegulationRetinaRetinal DegenerationRetinal DiseasesRetinal DisorderRetinitis PigmentosaRibosylhypoxanthine MonophosphateRoleSensorySightSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStructureSupplementationTapetoretinal DegenerationTestingTherapeutic InterventionTimeTransphosphorylasesUnited StatesViralVisionVisual ReceptorVisual Transductionautosomebalancebalance functionbiological signal transductioncell sortingcell transductioncellular transductiondegenerative retina diseasesdifferentiation protocolearly experienceearly onsetenzyme activitygenome mutationglycogen synthase a kinasehiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellshydroxyalkyl protein kinaseinduced human pluripotent stem cellsintervention therapymembermouse modelmurine modelnovelpathwayphosphorylase b kinase kinasepreservationpreventpreventingprotein protein interactionretina degenerationretina diseaseretina disorderretinal degenerativeretinal degenerative diseasesretinal dehydrogenase 1retinopathyrod and cone dystrophyrod-cone dystrophysocial rolespatial and temporalspatial temporalspatiotemporaltargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttransduced cellstreatment strategyvision lossvisual cyclevisual functionvisual lossvisual phototransduction
Description preview
PROJECT SUMMARY
Patients with retinitis pigmentosa (RP) due a mutation in inosine monophosphate dehydrogenase 1 (IMPDH1) expe-
rience an early onset and debilitating retinal degeneration that leads to blindness. IMPDH1, a critical enzyme in the
de novo synthesis of guanine nucleotides, places it at the nexus of cellular homeostasis. While guanine…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click