grant
Reducing Off-Target Accumulation of Chemotherapeutic Nanomedicines
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 1 Mar 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2025Adverse effectsAffectAnti-Cancer AgentsAntibodiesAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsAntitumor ResponseAttenuatedBacteriaBiodistributionBody TissuesCancer DrugCancer ModelCancer TreatmentCancerModelCell Communication and SignalingCell SignalingCirculationClinicCommunicationComplexDataDepositDepositionDoseDoxorubicin LiposomeDrug DeliveryDrug Delivery SystemsDrug TargetingDrugsEffectivenessEpitheliumExhibitsExposure toExtravasationFoundationsGoalsHairIFNImmuneImmunesImmunocompetentInfectionInflammatoryInjectionsInnate Immune ResponseInnate ImmunityInterferonsIntestinalIntestinesIntracellular Communication and SignalingInvadedLeakageLiposomal DoxorubicinLiposomal-Encapsulated DoxorubicinLiverMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant Tumor of the OvaryMalignant neoplasm of ovaryMammaliaMammalsMedicationMiceMice MammalsModelingMonitorMucosaMucosal TissueMucous MembraneMurineMusNative ImmunityNatural ImmunityNeoplastic Disease Chemotherapeutic AgentsNon-Specific ImmunityNonspecific ImmunityOrganOvary CancerPegylated Liposomal DoxorubicinPharmaceutical PreparationsPharmacodynamicsPhenotypeQOLQuality of lifeRouteS-Liposomal DoxorubicinSignal TransductionSignal Transduction SystemsSignalingSkinSpecificitySpillageSpleenSpleen Reticuloendothelial SystemStealth Liposomal DoxorubicinSterically Stabilized LiposomeSystemTherapeuticTissuesToxic effectToxicitiesToxicologyTranslatingTumor CellTumor-Specific Treatment AgentsViralViral DiseasesVirusVirus DiseasesVirus-like particleWorkanti-canceranti-cancer druganti-cancer therapyanti-tumor effectanti-tumor responseantitumor effectattenuateattenuatesbiological signal transductionbowelcancer microenvironmentcancer therapycancer-directed therapychemotherapycombatcytokinedrug distributiondrug/agentexperimentexperimental researchexperimental studyexperimentsfoothepatic body systemhepatic organ systemimmune competentimprovedin vivoinnovateinnovationinnovativemouse modelmurine modelnanonano medicinalnano medicinenano particlenano particulatenano-sized particlenanodrugnanomedicinalnanomedicinenanoparticlenanoparticulatenanopharmaceuticalnanosized particleneoplastic cellnew approachesnovel approachesnovel strategiesnovel strategyovarian cancerpathogenpreventpreventingprogramsresponseside effectsmall moleculesynergismtherapeutically effectivetranscytosistumortumor microenvironmentuptakeviral infectionvirus infectionvirus-induced diseasevirus-like nanoparticlesviruslike particle
Description preview
The work described in this proposal investigates a novel approach to reduce drug accumulation in healthy
tissues and improve the efficacy of chemotherapy. More specifically, we take advantage of recent studies
demonstrating an innate immune response (epithelial tightening) that limits viral infection, and our preliminary
data show that this…
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