grant
Recovery of reward function in nicotine use disorder using a combination of robotics, electrophysiology, and TMS
Organization RUTGERS THE STATE UNIV OF NJ NEWARKLocation NEWARK, UNITED STATESPosted 30 Sept 2022Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY2026AbstinenceAddressAnteriorBehaviorBiological MarkersBrain regionCell Communication and SignalingCell SignalingChronicCigaretteClimactericClinicalCompensationDecision MakingDropoutDrug usageDrugsEEGEffectivenessElectroencephalogramElectroencephalographyElectrophysiologyElectrophysiology (science)FDA approvedGoalsHealth Care SystemsHypersensitivityIQ DeficitInterventionIntracellular Communication and SignalingInvestigationLaboratoriesLifeLong-Term EffectsLong-Term PotentiationMedicationMental DepressionMethodsMonitorMotionNeurocognitiveNeurocognitive DeficitNeuronal DysfunctionNeurophysiology / ElectrophysiologyNicotine DependenceNicotine Use DisorderPerformancePersonsPharmaceutical PreparationsPhasePhysiologic pulsePrefrontal CortexProceduresProcessProtocolProtocols documentationPulseRecoveryResearchRewardsRoboticsRoleSeveritiesSignal TransductionSignal Transduction SystemsSignalingSmokerSmoking BehaviorStructureSubstance Use DisorderSubstance abuse problemTechnologyTestingTranscranial magnetic stimulationTreatment Efficacyabuse of substancesabused drugabused drugsbio-markersbiologic markerbiological signal transductionbiomarkerbrain basedcravingdecision-making capacitydepressiondetermine efficacydevelop therapydrug abstinencedrug abuseddrug of abusedrug relapsedrug usedrug/agentdrugs abuseddrugs of abuseefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationelectrophysiologicalevaluate efficacyexamine efficacyhigh riskimage guidanceimage guidedindexinginnovateinnovationinnovativeintelligence quotient deficitintervention developmentintervention efficacylife changeneural dysfunctionneural imagingneuro-imagingneurocognitive declineneurocognitive impairmentneuroimagingneurological imagingnew approachesnicotine addictionnicotine cravingnicotine dependentnon-invasive brain stimulationnovelnovel approachesnovel strategiesnovel strategyrobot assistancerobot assistedrobotic assistancesocial rolesubstance abusesubstance use and disordersubstance usersuccesstherapeutic efficacytherapy developmenttherapy efficacytreatment developmenttreatment programtreatment risk
Description preview
PROJECT SUMMARY/ABSTRACT
Substance use disorders (SUDs) are associated with reward-related abnormalities of the anterior midcingulate
cortex (MCC), a brain region strongly implicated in goal-directed decision-making. Our recent findings show the
reward positivity, an electrophysiological signal believed to index sensitivity of the MCC to rewards,…
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