grant
Rechargeable Anti-thrombogenic Films for Blood Contacting Applications
Organization BETH ISRAEL DEACONESS MEDICAL CENTERLocation BOSTON, UNITED STATESPosted 1 Jan 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2026Anticoagulant AgentsAnticoagulant DrugsAnticoagulantsArteriesAssistive TechnologyAutomobile DrivingBindingBiodegradationBloodBlood Reticuloendothelial SystemCarbohydratesCardiopulmonary BypassCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemChargeClinicalClosure by LigationComputational toolkitDevelopmentDevicesDiameterDirected Molecular EvolutionDomestic RabbitDrug KineticsEnzyme GeneEnzymesFamilyFilmGenerationsHPSE ProteinHeart VascularHeart-Lung BypassHeparanase-1HeparinHeparin BindingHeparinic AcidHumanImplantIn SituIn VitroInvestigationInvestigatorsLeannessLigationMaintenanceMapsMediatingModern ManMolecular InteractionMolecular TargetNatural regenerationNew ZealandOryctolagus cuniculusOutcomePBMCPathway interactionsPeptidesPerformancePeripheral Blood Mononuclear CellPharmacokineticsPhaseProcessPropertyProtein EngineeringProteinsRabbitsRabbits MammalsRecombinantsRegenerationReportingResearch PersonnelResearchersResistanceRiskSchemeSelf-Help DevicesSortingStentsSurfaceT-Cell EpitopesT-Lymphocyte EpitopesTherapeutic UsesThinnessThrombaseThrombinThrombomodulinThrombusTransgenic MiceVariantVariationVascular GraftVenousVentricularanalogassisted deviceassistive deviceblood thinnercirculatory systemcomputational studiescomputational toolboxcomputational toolscomputational toolsetcomputer studiescomputerized toolsde-immunizationde-immunizedeimmunizationdeimmunizedesigndesigningdevelopmentaldirected evolutiondrivingexperimentexperimental researchexperimental studyexperimentsfabricationfibrinogenasegenetic protein engineeringheart bypassheparan sulphate endoglycosidaseheparanaseheparin boundimmunogenicimmunogenicityimplant coatingimplantationimprovedin vivoinnovateinnovationinnovativelead candidatematerials sciencemutantnovelpathwayprotein designregenerateresistantrespiratory assistrespiratory assistanceresponsesortasesrtA gene productstructural biologysurface coatingthrombogenesisthrombogenicitythrombopoiesis inhibitorthrombotictooltranspeptidation
Description preview
Project Summary
Recent innovations by project investigators have established an important new framework for sustaining
the anti-thrombotic properties of blood contacting films in order to improve the clinical performance of a variety of
implanted cardiovascular devices. Notably, we have discovered highly active, orthogonal sortase mutants that…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click