grant
Real-Time, Non-Invasive Thrombus Characterization using Ultrasound Responsive Nanodroplets
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 20 Sept 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025AcousticsAgeAgingAnticoagulant AgentsAnticoagulant DrugsAnticoagulantsBiochemicalBiodistributionBiologicalCardiac infarctionCardiovascular DiseasesCessation of lifeCharacteristicsCirculationClinicalClottingCoagulationCoagulation ProcessCollagenCommon Rat StrainsConnective TissueDataDeathDepositDepositionDetectionDevelopmentDiagnosisDiagnostic MethodDiagnostic ProcedureDiagnostic TechniqueDrug DeliveryDrug Delivery SystemsDrug KineticsEffectivenessElasticityExposure toFibrinFibrinolytic TherapyFluorocarbonsFocused UltrasoundForce of GravityFoundationsGeneral RadiologyGoalsGravitiesHealthHistologicHistologicallyHistoryHydrogelsIn SituIn VitroInferior Vena CavaInferior vena cava structureInterventionIschemic StrokeLiquid substanceMechanicsMedicalMethodologyMethodsMicrobubblesModelingModulusMonitorMorbidityMorbidity - disease rateMyocardial InfarctMyocardial InfarctionNatureOutcomePatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPenetrationPerfluorocarbonsPersonsPharmacokineticsPhase TransitionPhlebothrombosisPhysical condensationPorosityProcessPropertyPulmonary EmbolismPulmonary HypertensionRadiologyRadiology SpecialtyRatRats MammalsRattusRecording of previous eventsRecoveryResearchRheologyRiskSafetySelection for TreatmentsSiteSpecificityStructureTechniquesTestingTherapeutic ThrombolysisThrombolytic TherapyThrombosisThrombusTimeUnited StatesVenousVenous Thrombosisage related pathwaysagesaging associated mechanismaging mechanismaging pathwayaging related mechanismaging related pathwaysbiologicbiological mechanism of agebiological pathways of ageblood thinnercardiac infarctcardiovascular disordercondensationcontrast imagingcoronary attackcoronary infarctcoronary infarctioncost effectivenesscrosslinkcustomized therapycustomized treatmentdesigndesigningdevelopmentalfluidheart attackheart infarctheart infarctionhistoriesin vivo Modelindividualized medicineindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentinsightintravenous administrationliquidmechanicmechanicalmechanical propertiesmechanism regulating agingmechanisms involved in agingmortalitynanoDropletnovelpathway involved in agingpatient centeredpatient orientedpatient oriented outcomespatient specific therapiespatient specific treatmentscreeningscreeningsselection of treatmentspatial and temporalspatial temporalspatiotemporalsuper high resolutionsuperresolutiontailored medical treatmenttailored therapytailored treatmenttherapy selectionthrombopoiesis inhibitorthrombotic diseasethrombotic disordertime usetooltreatment centertreatment selectiontreatment strategyultra high resolutionultrasoundunique treatmentvaporization
Description preview
ABSTRACT
Thrombosis is a leading cause of morbidity and mortality worldwide, associated with several serious health
complications including pulmonary hypertension, cardiovascular disease, and death. As thrombi mature, their
structural and mechanical properties change, becoming mechanically less compliant due to fibrin crosslinking
and gradual…
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